Summary
SUMMARY Despite intense research focus, Staphylococcus aureus has remained an important cause of both community acquired pneumonia and viral-related super-infections. The field has recently determined host mediated mechanisms induced by S. aureus that drive lung infection and injury. In the context of preceding influenza infection, our group and many others have delineated aberrant immune pathway regulation as key drivers of S. aureus susceptibility and pathogenesis. In addition to host mediated interactions, S. aureus expresses a number of secreted and cell wall virulence factors that have no
