Summary
Project Summary/Abstract Overlapping pain conditions greatly exacerbate patients’ pain experience. This includes comorbid migraine and temporomandibular disorders (TMDs), which is associated with a reciprocal increase in their prevalence/severity, increased risk of chronification, negatively impacting therapeutic outcomes. This underscores this comorbidity as a significant public health concern. However, little is known of its underlying pathobiology, highlighted by a dearth of validated animal models and a lack of evidence-based treatment approaches. Investigations into the underlying molecul
