Summary
Project 3 Abstract Intriguing evidence implicates reactive astrogliosis as impairing brain fluid dynamics (BFD) via multiple mechanisms, including 1) altering expression of the aquaporin-4 (AQP-4) water channel along the astrocytic end feet which line perivascular spaces and 2) modifying cerebrovascular vasomotion, a likely driver of perivascular fluid flow. In turn, impaired BFD may lead to reduced clearance of β-amyloid (Aβ), resulting in aggregation and Aβ plaque deposition. However, the temporal order of reactive astrogliosis, altered AQP-4 expression, impaired BFD, and Aβ deposition along
