Summary
Inflammation of the brain plays a major role in diseases such as stroke and dementia. Delivering medicines to the brain is difficult because often they do not reach damaged brain tissues. This CAREER project will produce biomimetic nanoparticles that have molecules specifically targeting brain blood vessels. The project will determine how the nanoparticles adhere to and cross inflamed brain blood vessels in disease-mimicking models. The project will integrate nanotechnology, bioengineering, vascular biology, and neuroscience to find how engineered biomimetic nanoparticles interact with diseas
