Summary
This proposal seeks to develop new statistical methods applicable to studies of bundled interventions. Randomized clinical trials, including in dental research, often focus on multi-component and other complex interventions. Using such ‘bundled’ interventions is appealing as a way to increase power – as well as simplicity - of the study. An apparent disadvantage is that it is not clear how to assess the effects of individual components of bundled interventions, which of also of frequent interest. While the measurement of treatment compliance, and use of causal mediation analysis is commonly re
