Summary
PROJECT SUMMARY/ABSTRACT Mechanisms underlying sustained weight loss after bariatric surgery remain unclear, though rapid nutrient delivery is a major candidate driving decreases in caloric intake via the gut-brain axis. Preclinical models have demonstrated the importance of the gut-brain axis in modulating short- and long-term feeding and taste preferences through gut-brain neural connections and the endocrine gut peptide response. Our clinical preliminary data demonstrates that rapid intestinal nutrient infusion (bypassing the stomach) in non-surgical patients with obesity can mimic the augm
