Summary
What can allow a few isolated cases of an infectious disease to blossom into an outbreak and further expand into a true pandemic? This is the driving question for the Center for Analysis and Prediction of Pandemic Expansion (APPEX). Biomedical and physical, ecological, socio-behavioral, economic, built and natural environmental, and information access factors are all likely to contribute to these perfect storm scenarios. In isolation, the contribution of each aspect may seem minor, or even overlooked, only leading to serious impacts when acting in synergy. This vastly complicates how to study,
