Summary
Abstract There are numerous examples of endogenous and exogenous particle-induced chronic inflammation. One model of chronic environmentally-induced inflammation is driven by exposure to crystalline silica particles. There are various occupational lung diseases that arise from exposure to exogenous particles such as asbestos fibers and crystalline silica (cSiO2) leading to chronic inflammation and lung fibrosis, however there are insufficient treatment options. A commonality of particle-induced inflammation is lysosome membrane permeabilization (LMP), in macrophages. Previous studies have show
