Summary
PROJECT SUMMARY Antimicrobial resistance increasingly threatens our ability to effectively treat a wide range of infections. Absent the development of novel antibiotics, humanity faces the prospect of a return to the pre-antibiotic era with associated mortality to rival that of cancer. One promising approach for the development of novel antibiotics is the engineering of antimicrobial peptides (AMPs), miniproteins of diverse structural classes made by all branches of life to defend against microbes. In particular, the engineering of human AMPs presents the opportunity to leverage both the antim
