Summary
Project Summary/Abstract (underlined are the added text and data related to this administrative supplement) Despite cancer being typically depicted as a genetic disease, aberrations in epigenetic regulation and gene expression play a determinant role in transformation and response to therapies. Increased chromatin plasticity gives a survival advantage by expanding epi-clones' repertoire and allowing them to react to the immune system, environmental stress, or exogenous treatments. Investigating which genetic and epigenetic aberrations alter chromatin homeostasis and how they shape tumor hetero
