Summary
PROJECT SUMMARY In recent years, adenosine has been identified as an important therapeutic target due to its observed immunosuppressive effects in the tumor microenvironment. By agonism to adenosine receptors, adenosine is a broad suppressor of immune function, decreased cytotoxic activity of T cells and NK cells, and increased differentiation of T cells to T regulatory cells. In the tumor microenvironment adenosine are elevated due to the overwhelming release of adenosine triphosphate and nicotinamide adenine dinucleotide, both of which are degraded to adenosine in the extracellular environme
