Summary
Project Summary Many processes essential for HIV-1 viral replication are driven by the association of regulatory RNA elements in the retroviral genome and host/viral proteins that form biologically active complexes. Despite advances in solving the 3D structures of RNA-protein complexes and in measuring RNA-protein interactions in vitro and in cells, our current understanding of RNA-protein interactions is qualitative and not quantitative, descriptive, not predictive. Attaining a quantitative and predictive understanding is necessary to reveal the forces and conformational states driving viral
