Summary
PROJECT ABSTRACT Sepsis is a life-threatening condition characterized by a dysregulated response to infection, leading to significant organ dysfunction and affecting 75,000 children and one million adults each year. The estimated yearly impact of this disease is 200,000 lives lost and $20 billion dollars in healthcare expenditures. Unfortunately, many initially promising sepsis therapeutics have failed to show wide benefit with tested in wider clinical trials. However, post-hoc analyses of some of these therapeutics demonstrate benefit to specific subgroups, raising concern that failure of sep
