Summary
PROJECT ABSTRACT Proteome integrity is maintained by a complex network that regulates protein synthesis, folding, transport, and degradation. Lysosomes are the catabolic center of a cell and central to maintaining proteome homeostasis by preventing, detecting, and removing abnormal proteins. Major knowledge gaps remain in the regulation, structural components, and substrate specificities of lysosomal substrates. Intracellular proteolysis through the ubiquitin-proteasome system has been the most well-characterized eukaryotic proteolytic pathway as the protein targeting by ubiquitin and the amin
