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Targeting Donor Regulatory Dendritic Cells During Normothermic Ex Vivo Liver Perfusion to Overcome Rejection after Liver Transplant

US National Institute of Allergy and Infectious Diseases grant open #nih-5K08AI155816-05

Summary

ABSTRACT This proposal presents a five-year research career development program focused on targeting donor liver- resident cells with regulatory properties to decrease rejection after transplantation. I am an Assistant Professor of Surgery at the University of Wisconsin-Madison, with previous research and clinical experience in transplant immunology and transplant surgery involving normothermic ex vivo machine perfusion (NEVLP), whereby an organ is housed under physiologic conditions. The present project will advance the field of transplant immunology by using NEVLP technology to modify the i

Targeting Donor Regulatory Dendritic Cells…
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