Summary
PROJECT SUMMARY The goal of this R21 project is to build a research platform to assess senescence-associated secretory phenotype (SASP) in vivo. A prominent feature of cellular senescence is the secretion of diverse biologic factors (cytokines, chemokines, proteases etc), collectively referred to as the SASP. Indeed, the SASP is hypothesized to be a key player in driving age-related diseases. However, SASP has been characterized almost exclusively in vitro due to the challenge of identifying the source of a secreted protein in vivo. Moreover, the field has been challenged by disentangling SASP
