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Host integration of commensal and pathogenic bacterial-derived signals

US National Institute of Diabetes and Digestive and Kidney Diseases grant open #nih-5R01DK116868-08

Summary

PROJECT SUMMARY Enteric bacterial infections remain one of the greatest public health challenges worldwide and deciphering the mechanisms that protect against infection will enable development of new treatments. Intestinal tissues are in constant direct contact with diverse beneficial and pathogenic microbes, highlighting the need for orchestrating complex microbial signals to sustain protection against infection. Intestinal epithelial cells (IECs) reside at the direct interface between intestinal pathogens, beneficial commensal bacteria, and intestinal immune components. However, despite cont

Host integration of commensal and pathogen…
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