Summary
Project Summary/Abstract Microglia play diverse roles in neurodegenerative disorders such as Alzheimer’s disease, multiple sclerosis, and the motor neuron diseases amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). Recent studies have revealed subtypes of microglia with varying molecular signatures and functions, indicating differential responses to stimuli and environmental cues. This heterogeneity suggests that microglia have distinct downstream effects on disease progression. Importantly, breakdown of blood-CNS barriers (BCNSBs; e.g., blood-brain and blood-spinal cord ba
