Summary
The cell nucleus houses different types of non-DNA substructures, called nuclear bodies. Among these, nuclear speckles predominate. Speckles occupy ~15-30% of the nuclear volume and are present in cells throughout our bodies. Proteins involved in different stages of RNA production are highly concentrated within speckles, and speckles are the key nuclear body that associates with active euchromatin. How speckles regulate gene expression has historically been murky due to lack of mechanistic insight. My past and current research centers on the view that nuclear speckles regulate gene expression
