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Synergistic Effects of Unacylated Ghrelin and Endurance Exercise on Sarcopenia and Mobility Loss

US National Institute on Aging grant open #nih-1R01AG092766-01A1

Summary

Project Summary/Abstract Sarcopenia, the progressive loss of muscle mass and function, universally impacts the aging population, contributing to loss of mobility and independence in older adults. With the rapid growth of the aging population, there is an urgent need for effective strategies against sarcopenia. Exercise is the most effective intervention that increases muscle mass and function in younger adults, but its benefits are attenuated in older adults due to diminished responses to exercise training. Over the years, several candidate molecules, including metformin, antioxidants, and res

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