Summary
Structure and Function of the Nuclear Pore Complex by Cryogenic-EM Abstract The nucleus is compartmentalized by double membranes of the Nuclear Envelope (NE) and macromolecules must cross this barrier during cell growth and differentiation. The Nuclear Pore Complex (NPC) forms a conduit for the bidirectional transport of proteins and RNA-protein complexes between the cytoplasm and nuclear interior. Regulated access to this gateway is used to control gene expression. Together, four co-axial rings form a cylindrical scaffold comprised of Nucleoporins (Nups). This scaffold anchors Nups with flexi
