Summary
Our studies focus on cellular signaling pathways that regulate cell proliferation, focusing on the location, timing and progression of DNA synthesis in cancer cells. Since many regulatory pathways that affect chromosome duplication are deregulated in cancer, our findings can facilitate understanding the regulation of cancer cell proliferation and the determinants of response to chemotherapeutic drugs. Our current research plan is built on our previous findings, which include whole-genome-scale mapping of replication initiation sites (replication origins) in human cells, identification of chrom
