Summary
Project Summary Animal models are critical for biomedical research. They allow us to rapidly test the importance of any gene for development or diseases. Advances in technology now allow us to reduce or eliminate protein expression in the entire animal or in selected tissue. Similarly, mutations in the coding sequence of a gene associated with a disease can be introduce in animal model to test if they are indeed responsible for the disease state. Antibodies are critical tools to study protein localization and function. They can be used to block a protein function, send it for degradation, immu
