Summary
Summary – Project 1 Project 1 will study the ∆-Ecology of tumor-immune interactions in NSCLC, with a focus on KRAS-mutant cancers. Immunotherapy has demonstrated response rates of 30 to 45%. Most responses are followed by evolution of resistance and progression. Recently we have quantified the immune ecology of these cancers from pre-treatment biopsies and found unique ecological interactions that predetermine therapy response. A focus of this proposal will be to use both pre- and on-treatment biopsies from a clinical trial to quantify the immune ∆-Ecology during therapy. We will use a computa
