Summary
PROJECT 3 – PROJECT SUMMARY Aberrant secondary immune activity after brain injury during neonatal life affects critical phases of brain development, with long-lasting behavioral abnormalities relevant to neurodevelopmental disorders. The most common form of brain injury in the preterm neonate is germinal matrix hemorrhage (GMH), which may display pathophysiological alterations relating to risk factors for atypical brain development. However, very little is known about how an aberrant secondary immune response that occurs and persists in the higher-order cortical and limbic regions of the devel