Summary
Project Summary This study seeks to advance heterobifunctional degraders that induce targeted protein degradation through the ubiquitin proteasome pathway. Typically, molecular degraders involve a ligand that recruits an E3 ubiquitin ligase and another that targets a protein of interest (POI), forming an E3:Degrader:POI ternary complex, leading to POI ubiquitination and subsequent degradation by the 26S proteasome. Peptide-based proteolysis targeting chimeras (PepTACs) offer distinct advantages over small molecule degraders for targeting protein-protein interactions due to their specificity, m
