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Development of Animal Models and Related Biological Materials for Research (R21 Clinical Trial Not Allowed)

US · MD · Bethesda National Institutes of Health (NIH) grant open #PAR-25-273
Response due Jan 07, 2028 · 00:00 UTC

Summary

This NIH funding opportunity announcement (FOA) under the R21 mechanism solicits applications for the development of animal models and related biological materials to support biomedical research. Clinical trials are explicitly excluded from this opportunity. The R21 mechanism is designed to encourage exploratory and developmental research projects. The opportunity is open for a multi-year period from November 2024 through January 2028, allowing for multiple submission cycles.

What they want

Applicants must propose development of novel animal models and/or related biological materials (e.g., transgenic animals, knock-out/knock-in models, disease models, or associated reagents and biological materials) intended to advance biomedical research. Clinical trials are not allowed under this announcement. Projects must align with the NIH R21 exploratory/developmental research grant mechanism, which typically supports early-stage, high-risk/high-reward research efforts.
Technical requirements
  • No clinical trials allowed
  • Must use R21 exploratory/developmental research grant mechanism
  • Focus on development of animal models and/or related biological materials

How they evaluate

Submission: Grants.gov federal grants portal (electronic submission)

Risks & flags

  • Multi-year open window (2024–2028) suggests a broad programmatic FOA rather than a targeted competitive procurement — standard for NIH omnibus announcements
  • No dollar value stated; award amounts are at NIH's discretion per R21 guidelines

Market context

inferred from NAICS
Professional, Scientific & Technical Services
NAICS 541714
US market size
$2.0T
Typical award
$25K – $50M
Typical buyers
All federal civilianDoDStates
Commonly required
8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.

Development of Animal Models and Related B…
Due Jan 07
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