Summary
PROJECT SUMMARY/ABSTRACT The three-dimensional organization of eukaryotic genomes plays a crucial role in transcriptional regulation and cellular functions. However, current genome structure models, primarily derived from genomic data, have significant limitations. They lack precise physical dimensions, fail to capture nuclear morphologies accurately, and are constrained by a resolution limit of approximately 200 kb—insufficient for studying interactions between regulatory control regions. These shortcomings hinder the use of 3D genome structures in understanding gene regulation and cellular p
