Summary
Abstract Dementia is associated with staggering economic, social, and personnel costs. Strikingly, most dementia cases have co-pathologies beyond the dominant type. Research suggests these non-dominant protein aggregates can impact cognition, symptoms, and progression. These findings motivate our central hypothesis that individual pathologies uniquely contribute to the degenerative trajectory of clinical dementia. Our long-term goal is to build a model of degenerative dementia that is inclusive of co-pathology. Accomplishing this goal requires identifying pathologies and determining how each p
