Summary
PROJECT SUMMARY / ABSTRACT Retinitis pigmentosa (RP) is the most common hereditary cause of blindness, affecting over 1.5 million people worldwide. RP has an extraordinarily variable etiology, with over 5,000 distinct mutations in more than 300 genes implicated in its pathogenesis, which suggests that the most productive therapeutic interventions would employ gene-independent strategies to target the cellular pathology shared across many mutations and patient groups. Our lab has demonstrated that one such common pathology is the impairment of cellular proteostasis. This condition arises from
