Summary
PROJECT SUMMARY/ ABSTRACT. Chronic pain is a common debilitating condition that often leads to the prescription of escalating opioid doses and has created a nationwide severe crisis. In September 2022, the American Medical Association issued a report entitled "Nation's opioid-related overdose and death epidemic continues to worsen," which stated more than 107,000 deaths were reported in the United States between December 2020 and December 2021. Therefore, there is an urgent need to develop novel, non-opioid, and non-addicting therapies that are effective in chronic pain management. Previous be
