Summary
ICAL ANALYTICAL CORE: SUMMARY The NIDA Center of Excellence Impact of Cannabinoids Across the Lifespan (ICAL), whose renewal is proposed in this revised application, tests the hypothesis that non-physiological activation of the endocannabinoid system during adolescence – caused by exposure to D9-tetrahydrocannabinol (THC) – initiates a reprogramming of the genetic and epigenetic processes that govern this system’s molecular structure, neuroanatomical architecture, and synaptic functions, ultimately producing persistent abnormalities in cognition and motivated behavior. In the first funding per
