Summary
Project Summary/Abstract Phenotype control, an active area of research in network control, is applicable to interacting biomolecular systems and can identify targeted interventions that lead to desired cell phenotypes. Phenotype control distinguishes itself from classical control theory in that (i) its objectives are related to dynamical attractors (e.g., stable states), and (ii) its interventions don’t need to be continuously adjusted based on the state of the system. This type of control is well-suited for guided cell differentiation, inducing cell fate changes, or inducing apoptosis of a ta
