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Showing 25 / 20086 · page 10/804
The role of heme in retinal vascular development and disease
US · IL NIH · NAICS 541714 · grant
PROJECT ABSTRACT Retinal vascular diseases are major causes of vision loss in the United States and around the world. To better treat these disorders, we need to understand the signaling pathways that control the growth and integrity of ret…
Posted May 21, 2026
The Interdisciplinary Training, Education and Research Activities for Assessing and Controlling Contaminants from Emerging Technologies (InTERACCT) Program
US National Institute of Environmental Health Sciences · grant
PROJECT SUMMARY To ensure that emerging technologies grow without causing illness or injury to workers and the public, a professional workforce must be prepared with the ability to anticipate, recognize, evaluate, and control exposures to h…
Posted May 21, 2026
Biomarkers Core (Core E)
US National Institute on Aging · grant
SUMMARY: CORE E- BIOMARKER CORE. The Biomarker Core supports the Harvard Aging Brain Study (HABS) Program Project Grant (PPG) by processing and banking blood (plasma, serum, whole blood, buffy coat, RNA, miRNA, DNA and cell lines) and cereb…
Posted May 21, 2026
Pharmacokinetic and pharmacodynamic relationships for antibacterial treatment of shigellosis
US National Institute of Allergy and Infectious Diseases · grant
Project Summary/Abstract Enteric infection with Shigella spp. can lead to symptoms ranging from acute watery diarrhea to sudden, severe dysentery. Approximately 212,000 diarrheal deaths annually are attributed to Shigella (12.5% of total d…
Posted May 21, 2026
Modex, a cloud-based, centralized health economic model marketplace to reduce costs and enhance equity in cancer
US National Cancer Institute · grant
New cancer drugs have long been at the forefront of research and debate about rising healthcare expenditure in the United States; researchers and decision-makers rely on evidence to support fair pricing and ensure patient access. HE models …
Posted May 21, 2026
The role of alpha-synuclein in nucleolar DNA double-strand break repair and cellular senescence
US National Institute on Aging · grant
PROJECT SUMMARY Genomic stability is very closely linked to diseases associated with aging, like neurodegeneration and cancer. Interestingly, strong evidence suggests unexpected links between these two diseases, since epidemiological studie…
Posted May 21, 2026
FRESH Network: Assisting Mansfield Schools with Understanding Contanimants in School Meals and Transitioning to Better Food Systems
US Food and Drug Administration · grant
Project Abstract Mansfield School District (Arkansas) FRESH Network: Assisting Mansfield Schools with Understanding Contaminants in School Meals and Transitioning to Better Food Systems Across Arkansas and much of the country, school meals …
Posted May 21, 2026
Development of synthetic heparin to protect liver graft from ischemia reperfusion injury during transplantation
US · IL NIH · grant
Project Summary/Abstract This STTR phase II application is to seek continuation support to develop a carbohydrate-based reagent, dekaparin, to protect from liver damage during the organ recovery and preservation process. Liver transplant is…
Posted May 21, 2026
Identifying and characterizing new therapy targets in TDP-43 proteinopathies
US · IL NIH · NAICS 541714 · grant
Project Summary: Age-related neurodegenerative diseases are a rapidly growing cause of mortality and morbidity worldwide. The overwhelming majority of neurodegenerative disease, referred to as ‘sporadic,’ is caused by poorly understood inte…
Posted May 21, 2026
CALIBER Dissemination and Community Engagement Core
US National Institute on Alcohol Abuse and Alcoholism · grant
The Dissemination and Community Engagement (DICE) Core advances the scientific mission of the CALIBER Center by closing the gap between research and practice through engaging with persons highly impacted by unhealthy alcohol use and HIV and…
Posted May 21, 2026
Investigating the RNA-Regulatory Activities of the RNA Exosome during Human Motor Neuron Differentiation
US · IL NIH · grant
Project Summary: Accurate stem cell differentiation requires precise gene regulation at both the transcriptional and post- transcriptional levels. While the transcriptional activation networks governing cellular differentiation are well cha…
Posted May 21, 2026
HIV reverse transcriptase structure, function, inhibition, and roles in viral assembly and maturation
US · IL NIH · grant
Project Abstract HIV remains a key health challenge, with fundamental aspects of the viral replication machinery remaining poorly understood. Building on our extensive studies of HIV-1 reverse transcriptase (RT) structure and function, we p…
Posted May 21, 2026
Methods for anterograde tracing of active circuits
US · IL NIH · grant
Project Summary A central yet unrealized goal of modern neuroscience is to map all the neural circuits within the brain and the changes that occur during development, learning, aging, and in disease states. Towards this end, we recently dev…
Posted May 21, 2026
Applying digital phenotypes and epigenetics to understand clinical outcomes in acute hypoxemic respiratory failure without acute respiratory distress syndrome (NAHRF)
US · IL NIH · NAICS 541714 · grant
PROJECT SUMMARY Each year approximately 1 million adults receive invasive mechanical ventilation in the United States for acute hypoxemic respiratory failure (AHRF), and 30-40% of these patients die in the hospital. Most research has focuse…
Posted May 21, 2026
Computational Feature Profiling and Modeling for Prostate Cancer Detection and Risk Stratification
US · IL National Institutes of Health (NIH) · NAICS 541715 · grant
PROJECT SUMMARY/ABSTRACT Prostate cancer is the most common and second deadliest non-skin cancer in American men, accounting for 26% of new cancer diagnoses and 9% of cancer deaths in men. Active surveillance, radical prostatectomy and radi…
Posted May 21, 2026
Hox gene regulation of body size and asexual reproduction underlie regenerative abilities
US · IL NIH · grant
Abstract The ability of certain animals to regenerate their cells and tissues has long been a subject of interest for biologists due to its relevance to animal development and regenerative medicine. However, we still don't fully understand…
Posted May 21, 2026
Effect of WASH interventions on population resilience to climate-driven enteric pathogen transmission along a gradient of socio-economic position
US National Institutes of Health · grant
Background: Most of rural Bangladesh is situated in the Ganges-Brahmaputra-Meghna river basin which is home to over 618 million people and represents one of the most climate-sensitive populations in the world. Living in the basin exposes th…
Posted May 21, 2026
Serologic measures of enteric pathogen transmission for intervention studies and population monitoring in low-resource settings
US · IL NIH · grant
Enteric pathogen infections cause an immense disease burden among children in low-resource settings. Understanding pathogen-specific transmission in high burden populations, and whether transmission is reduced through environmental interven…
Posted May 21, 2026
Seroepidemiology of trachoma for the elimination endgame
US · IL NIH · NAICS 541715 · grant
Trachoma, caused by ocular Chlamydia trachomatis infection, is the leading infectious cause of blindness worldwide and been targeted for global elimination as a public health problem by 2030. As we approach the endgame, there is broad inter…
Posted May 21, 2026
Effect of WASH interventions on population resilience to seasonally-driven enteric pathogen transmission along a gradient of socio-economic position
US · IL NIH · grant
Background: Most of rural Bangladesh is situated in the Ganges-Brahmaputra-Meghna river basin which is home to over 618 million people and represents one of the most vulnerable populations in the world to extreme weather events. Living in t…
Posted May 21, 2026
Enteric Pathogen Force of Infection among Children using Serology
US · IL NIH · NAICS 541714 · grant
Enteric pathogen infections are a leading cause of the global disease burden, with the largest burden among children in low-resource settings. Stool-based PCR methods have dramatically improved our ability to measure enteric infections, but…
Posted May 21, 2026
Transformative rat models to study sex differences in disease
US NIH Office of the Director · grant
Project Summary The long-term objectives are to develop and validate rat models of disease that allow investigators to measure the differential effects of XX and XY sex chromosomes that protect from or exacerbate disease. Most human diseas…
Posted May 21, 2026
Angiotensin-(1-7) and Hypothalamic control of blood pressure
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY Obesity is a global epidemic that is associated with excessive central sympathetic outflow to cardiovascular end organs to elevate blood pressure and predispose to hypertension. Accumulating evidence from our laboratory sugg…
Posted May 21, 2026
Angiotensin-(1-7) and Cardiovascular Derangements in Obesity Hypertension
US · IL NIH · grant
PROJECT SUMMARY Obesity is a global epidemic that is associated with sympathetic overactivation, endothelial dysfunction, and insulin resistance; all of which can contribute to hypertension development. Despite well-established clinical ass…
Posted May 21, 2026
Characterizing the role of anandamide in trauma-related hyperarousal during the menopause transition
US · IL NIH · NAICS 541715 · grant
Posttraumatic stress disorder (PTSD) is a debilitating mental health condition that disproportionately affects women, particularly those from underserved populations who face higher rates of trauma exposure. PTSD is associated with trauma-r…
Posted May 21, 2026