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Showing 25 / 20086 · page 11/804
Medical countermeasures to chlorine exposure based on GABA(A) receptor targeting
US National Institute of Environmental Health Sciences · grant
The proposed research will demonstrate the therapeutic efficacy of one or more gamma aminobutyric acid type A receptor (GABAAR) modulators in reducing acute lung injury (ALI) caused by inhaled chlorine. The research is significant because i…
Posted May 21, 2026
Longitudinal EEG and Environmental Trajectories Leading to ADHD and Disruptive Behaviors from Infancy to Preschool
US · IL NIH · grant
Project Summary Attention deficit hyperactivity disorder (ADHD) and disruptive behaviors (DBs) affect up to 9% of children. Under-diagnosis and under-treatment of ADHD and DBs disproportionately affect children with socioeconomic stress and…
Posted May 21, 2026
Elucidating the role of hepatic ketogenesis in pancreatic cancer cachexia and recovery
US · IL NIH · NAICS 541714 · grant
PROJECT SUMMARY/ABSTRACT 80% of patients with Pancreatic Ductal Adenocarcinoma (PDAC) develop cachexia, which results in dispropor- tionate skeletal muscle mass loss, relative to caloric deficits. Cachexia causes functional impairment and i…
Posted May 21, 2026
Targeting insomnia to improve outcomes in adults with problematic cannabis use
US National Institute on Drug Abuse · grant
Cannabis use, heavy cannabis use, and cannabis-related problems are becoming increasingly common in the United States. Among those who use cannabis regularly, significant insomnia is common. For example, our data from 800 patients seeking m…
Posted May 21, 2026
Structural characterization of the HIV-2 capsid lattice
US · IL National Institutes of Health (NIH) · grant
Project Summary/Abstract Human retroviral infections (i.e., human immunodeficiency virus type 1, HIV-1; and HIV type 2, HIV-2) impact a combined 38 million people worldwide and result in at least 680,000 deaths per year. Despite advancement…
Posted May 21, 2026
Mechanisms that Couple Chromatin Modifications to Transcription
US National Institute of General Medical Sciences · grant
Project Summary The goal of this research program is to elucidate the proteins and mechanisms that regulate transcription within the context of chromatin, a process critical to every eukaryotic cell. Nucleosomes pose barriers to RNA polymer…
Posted May 21, 2026
Toward efficient performance for deep learning on medical imaging
US National Heart Lung and Blood Institute · grant
Project Summary / Abstract Objective — The goal of this renewal is to continue developing and optimizing novel deep learning (DL) and related methods to improve diagnosis and clinical decision-making for congenital heart disease (CHD). Nota…
Posted May 21, 2026
Structure and Function of Integrins in the Kidney
US · IL NIH · grant
Abstract The stoichiometric cis association of the tetraspanin CD151 with podocyte integrin α3β1 is essential for stabilizing α3β1 in an active ligand-binding conformation, thus maintaining the integrity of the glomerular filtration barrier…
Posted May 21, 2026
Platelet alphaIIbbeta3 activation and its therapeutic targeting
US · IL NIH · grant
Abstract Platelet integrin αIIbβ3 plays a central and nonredundant role in hemostasis and thrombosis. It is normally kept in a default inactive conformation in resting free-flowing platelets in the circulation. Despite extensive efforts, it…
Posted May 21, 2026
Tobacco Mosaic Virus as a mucosal delivery platform for an intranasal vaccine against Pseudomonas aeruginosa
US · IL NIH · grant
Pseudomonas aeruginosa (PA) is a gram-negative opportunistic pathogen that is one of the most prominent causes of healthcare acquired infections worldwide. It is also a significant cause of morbidity and mortality associated with burn wound…
Posted May 21, 2026
Promoting Change in Practice for Respiratory Failure: the PRECIPICE Study
US · IL NIH RePORTER (National Heart, Lung, and Blood Institute - NHLBI) · grant
PROJECT SUMMARY Background: Approximately 300,000 Hispanic individuals experience respiratory failure each year in the U.S. Hispanic patients are twice as likely to die from respiratory failure as non-Hispanic patients. There is an urgent n…
Posted May 21, 2026
Defining mechanisms of action of Menin inhibition in AML
US · IL NIH · grant
Abstract Project 3 Acute myeloid leukemia (AML), and specifically KMT2A-rearranged (KMT2A-r) and NPM1 mutant AML, remain devasting disease with an overall poor prognosis for high risk pediatric and adult patients. AML is characterized by ab…
Posted May 21, 2026
Defining epigenetic mechanisms in NPM1c mutant leukemia
US · IL National Institutes of Health · grant
Project Summary/Abstract Nucleophosmin (NPM1) mutations are among the most common aberrations in acute myeloid leukemia (AML) and cause a characteristic stem cell-like gene expression pattern including the upregulation of HOXA/B cluster gen…
Posted May 21, 2026
1Florida Alzheimer's Disease Research Center Clinical Core
US National Institute on Aging · grant
The goal of the 1Florida ADRC is to advance the understanding of Alzheimer’s disease and Related Disorders (ADRDs), especially in underrepresented minority groups. Among 370 participants currently recruited at Mount Sinai Medical Center (…
Posted May 21, 2026
Cancer Control and Survivorship Program
US National Cancer Institute · grant
PROJECT SUMMARY/ABSTRACT—Cancer Control and Survivorship Program The overarching goal of the Cancer Control and Survivorship Program (CCSP) is to conduct highly innovative clinical, genetic, and observational research, and translate our f…
Posted May 21, 2026
Mach-LETSGO: Machine-LEarning of Treatment, Survey, and Genetics towards Obtaining Correct Classification of Chronic Conditions in Adult Survivors in the Childhood Cancer Survivor Study - CCSS Suppl
US · IL NIH · grant
ABSTRACT Mach-LETSGO leverages machine learning to improve the accuracy of chronic health condition classification in the Childhood Cancer Survivor Study (CCSS; U24 CA055727; PI: Armstrong), addressing limitations of its self- reported data…
Posted May 21, 2026
Childhood Cancer Survivorship Study
US · IL NIH · grant
ABSTRACT The Childhood Cancer Survivor Study (CCSS) is a multi-institutional, multi-disciplinary collaborative research resource established to systematically evaluate long-term outcomes among children diagnosed with cancer who survived fiv…
Posted May 21, 2026
Lung interstitial macrophage remodeling during and after recovery from pneumococcal respiratory infection
US National Heart Lung and Blood Institute · grant
Project Summary Worldwide, acute lower respiratory tract infections, including pneumococcal pneumonia, are a major cause of mortality among all infectious diseases. Streptococcus pneumoniae continues to be the leading cause of bacterial pne…
Posted May 21, 2026
C-type natriuretic peptide in hypertrophic cardiomyopathy
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY/ABSTRACT The overall objective of this proposal is to further our understanding of the biology and therapeutic potential of C-type natriuretic peptide in hypertrophic cardiomyopathy (HCM). Cardiac fibrosis a key risk factor …
Posted May 21, 2026
Improving the science of adherence reinforcement and safe mobility in people with diabetic foot ulcers using smart offloading
US · IL National Institutes of Health (NIH) · grant
PROJECT SUMMARY/ABSTRACT We aim to reduce the limb-threatening and life-limiting burden of neuropathic diabetic foot ulcers (DFU) by advancing science in its most critical component: protective pressure offloading. We intend to do this via…
Posted May 21, 2026
Using Open-Source Technology to Measure Energy Expenditure and Sleep Among Children 3 to 8 Years Old
US National Heart Lung and Blood Institute · grant
Assessing children’s 24-hour movement behaviors (i.e., time spent active, sedentary, and asleep) can reveal the complex and interdependent ways energy expenditure and sleep are related to health outcomes. However, assessing energy expenditu…
Posted May 21, 2026
Causes and Consequences of Preschooler's Digital Media Use: The Role of Sleep, Physical Activity, Sedentary Behavior and Social Emotional Health
US Eunice Kennedy Shriver National Institute of Child Health and Human Development · grant
Excessive screen time for children ages 3-5 years is linked with poor sleep, inactivity, and behavior problems. The WHO recommends children under 5 get <1 hour of screen time per day, but few children meet this guideline. This is partly att…
Posted May 21, 2026
Causes and Consequences of Preschooler's Digital Media Use: The Role of Sleep, Physical Activity, Sedentary Behavior and Social Emotional Health
US · IL National Institutes of Health (NIH) · NAICS 541715 · $unknown · grant
Excessive screen time for children ages 3-5 years is linked with poor sleep, inactivity, and behavior problems. The WHO recommends children under 5 get <1 hour of screen time per day, but few children meet this guideline. This is partly att…
Posted May 21, 2026
Light Microscopy Digital Imaging
US National Cancer Institute · grant
Abstract Light Microcopy & Digital Imaging (LMDI-SR) Light microscopy and digital imaging is integral to COHCCC’s research mission. The LMDI-SR provides a wide range of instruments that allow investigators to image numerous sample types in …
Posted May 21, 2026
Assessment of Treatment Satisfaction in Psoriasis
US · IL NIH · grant
PROJECT SUMMARY / ABSTRACT Treatments for plaque psoriasis vary substantially in effectiveness and side effects. It is often difficult to determine the optimal treatment during a patient-centric, shared decision-making process between the c…
Posted May 21, 2026