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Showing 25 / 20086 · page 12/804
Spatialomics and quantitative MRI of ischemic injury in a piglet model of Legg-Calve-Perthes disease
US · MN NIH RePORTER · grant
PROJECT SUMMARY This K01 award will provide training and protected research time for Alexandra Armstrong, DVM, DACVP, PhD to achieve her career goal of becoming an independently-funded investigator with specialty expertise in animal models …
Posted May 21, 2026
Peptide Nucleic Acid (PNA) Oligomers for Targeted Disruption of Biomolecular Condensates in ALS/FTD
US National Institute of Neurological Disorders and Stroke · grant
PROJECT SUMMARY The formation of biomolecular condensates (BMCs) is an important phenomenon in biology, creating transient compartments that can accelerate biochemical reactions or sequester molecules during times of stress. Aberrations in …
Posted May 21, 2026
Elucidating a novel respiratory-mammary axis of T cell immunity
US National Institute of Allergy and Infectious Diseases · grant
Breastfeeding is associated with immunological benefits that persist beyond infancy, including reduced risk of respiratory infection. While these benefits are often attributed to immunoglobulins and antimicrobial compounds, human milk is al…
Posted May 21, 2026
Outreach & Engagement Core
US · IL NIH · grant
Cancer is the second leading cause of mortality for Native Americans.1 In Arizona (AZ), only the Navajo Nation and the Hopi Tribe have Centers for Disease Control and Prevention funding through the National Breast and Cervical Cancer Early …
Posted May 21, 2026
Defining the role of lncRNA Neat1 and the nuclear paraspeckle in regulating macrophage innate immune gene expresison
US · IL NIH · grant
PROJECT SUMMARY To ensure a robust immune response to pathogens without risking immunopathology, the kinetics and amplitude of inflammatory gene expression in macrophages need to be exquisitely well-controlled. To mount balanced inflammator…
Posted May 21, 2026
Ecological Assessment of Proximal Risk Factors for Suicide During Care Transitions
US · IL NIH · NAICS 541720 · grant
Project Summary/Abstract Suicidal ideation and behavior are growing public health problems in the United States. This is particularly concerning during the high-risk period following discharge from psychiatric hospitalization when risk for …
Posted May 21, 2026
A Prospective, Longitudinal Investigation of Physical Activity and Bone Health among Female Adolescents Recovering from Restrictive Eating Disorders
US · IL NIH · grant
PROJECT SUMMARY/ABSTRACT Restrictive eating disorders (EDs) most commonly affect female adolescents and can lead to low bone mineral density (BMD) and impaired bone microarchitecture. Peak bone accrual occurs during adolescence, and the pr…
Posted May 21, 2026
Hands-on Science Education for Future Leaders in Biomedical and Behavioral Research
US National Institute on Drug Abuse · grant
The mission of this SEPA grant at California State University San Marcos (CSUSM) is to foster future scholars of science by engaging motivated youth and their families in a structured, comprehensive science education, mentoring, and researc…
Posted May 21, 2026
Novel Methods for Joint Prediction in the presence of mortality
US National Heart Lung and Blood Institute · grant
Project Summary and Abstract Health care decisions are made in challenging clinical settings where patients and physicians have to con- tend with complex trade-offs across a range of longitudinal and time-to-event quality-of-life outcomes …
Posted May 21, 2026
Extracellular Potassium and Astrocytic Kir4.1 Modulate Interneuron Activity in the Cerebral Cortex
US National Institute of Neurological Disorders and Stroke · grant
Astrocyte potassium buffering through the inwardly rectifying potassium channel, Kir4.1, is a crucial and essential function. Changes in Kir4.1 have been implicated in epilepsy, seizures, and several neurodegenerative disorders. However, un…
Posted May 21, 2026
Impact of polymicrobial interactions and within-host adaptation on CAUTI pathogenesis
US · IL NIH · grant
Project Summary/Abstract Urinary tract infection (UTI) is one of the most common infections worldwide and a leading cause of morbidity and healthcare expenditures across all ages. Older adults and individuals with catheters have a particula…
Posted May 21, 2026
The urothelial glycosaminoglycan layer: composition and contribution to pathogen fitness during catheter-associated urinary tract infection
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
Project Summary/Abstract Urinary tract infection (UTI) is one of the most common infections worldwide and a leading cause of morbidity and healthcare expenditures across all ages. Older adults and individuals with catheters have a particula…
Posted May 21, 2026
Evolution of Pseudomonas aeruginosa in premise plumbing and impact on cystic fibrosis respiratory disease pathogenesis
US National Institute of Allergy and Infectious Diseases · grant
Potable water is a major source of opportunistic pathogens that cause a variety of life-threatening infections in immunocompromised people, with a yearly US economic burden of $2.4 billion dollars. Biofilms ubiquitously coat surfaces within…
Posted May 21, 2026
Ultra-precision diagnostics for ALK+ non-small cell lung cancer
US · IL NIH RePORTER · NAICS 541714 · grant
Background & Significance: Identifying ALK-positive lesions, which are highly responsive to treatment with Crizotinib or Alectinib, is a high-priority for managing patients with ALK+ Non-Small Cell Lung Cancer (NSCLC). A blood-based compani…
Posted May 21, 2026
Cancer Research Training andEducation Coordination
US National Cancer Institute · grant
Training and education have a long-standing legacy at the Sidney Kimmel Comprehensive Cancer Center (SKCCC). The goal of this Cancer Research Training and Education Coordination (CRTEC) program is to coordinate and track the success of thes…
Posted May 21, 2026
Molecular Targets for Cancer Detection and Treatment
US · IL NIH · NAICS 611310 · grant
This Molecular Targets Training Program has to meet workforce needs for scientifically trained medical oncology physicians who will translate increasingly technical knowledge in molecular biology to advances for cancer patients. The Program…
Posted May 21, 2026
Cancer Genetics of Long Telomere Syndromes
US National Cancer Institute · grant
Abstract This application focuses on understanding the genetic basis of a recently recognized cancer-prone syndrome caused by long telomere length. It is driven by extended cellular longevity, a mechanism that is distinct from tumor suppres…
Posted May 21, 2026
Robotic System for Spinal Decompression and Interbody Fusion
US National Institute of Arthritis and Musculoskeletal and Skin Diseases · grant
Summary The goal of this application is to develop a robotic workstation with integrated, novel imaging and visualization capabilities to perform complex tasks in minimally-invasive spine (MIS) surgery that cannot be currently performed wi…
Posted May 21, 2026
Epigenetic mechanisms of regulation of histone lysine methyltransferases involved in leukemia
US National Institute of General Medical Sciences · grant
Chromatin conformation underlies accessibility of enzymes that participate in transcription, replication, recombination, and repair. Many chromatin-regulatory mechanisms ensure that enzymes such as RNA polymerase II gain access to and effic…
Posted May 21, 2026
Molecular basis for aberrant de novo DNA methylation in cancer
US · IL NIH · grant
PROJECT SUMMARY Methylation of cytosine in the context of CpG dinucleotides is an essential and highly conserved chromatin modification. It plays a critical role in gene regulation, cell differentiation and organismal development. Aberrant …
Posted May 21, 2026
Molecular Mechanisms of Chromatin Remodeling and Deacetylation
US · IL NIH · grant
Project Summary Chromatin structure and function are dynamically regulated by ATP-dependent chromatin remodelers and Sirtuin histone deacetylases, two critical enzyme families that play pivotal roles in DNA transcription, replication, repai…
Posted May 21, 2026
Evaluating the Effect of a Local Microvascular Tissue Graft Treatment in Rat Models of Diabetic Peripheral Neuropathy
US · IL National Institutes of Health · NAICS 541714 · small business · grant
PROJECT SUMMARY Diabetic peripheral neuropathy (DPN) is a progressive disease, and currently, there are no well-recognized effective treatments shown to be able to address DPN and improve or return sensation to extremities. MicroVascular Ti…
Posted May 21, 2026
Modeling ASD-linked genetic mutations in 3D human brain organoids
US · IL NIH · grant
Project summary / Abstract Autism spectrum disorder (ASD) is a neurodevelopmental disorder whose underlying mechanisms have been proposed to include abnormal excitatory-inhibitory balance in brain regions including the cerebral cortex. The …
Posted May 21, 2026
Neuron-Oligodendrocyte Communication Underlying Myelin Distribution in the Neocortex
US · IL National Institutes of Health · grant
Summary: Over vertebrate evolution, the development of the myelin sheath has contributed to the expansion of the central nervous system and the emergence of complex brain function. Cumulative evidence indicates that the level of myelination…
Posted May 21, 2026
Comprehensive single-cell atlas of the developing mouse brain
US · IL NIH · grant
PROJECT SUMMARY The developing mouse brain is a foundational experimental model for investigation of the origins of cell types in the mammalian brain. Comprehensive knowledge of mouse brain development is critical for comparative studies of…
Posted May 21, 2026