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Showing 25 / 20086 · page 13/804
Circulating and Brain Lipidomics, Cognition and Dementia
US National Institute on Aging · grant
Decline in cognition and the onset of Alzheimer’s disease (AD) and dementia impose a devastating personal and interpersonal burden with huge societal costs. To provide insights into new mechanisms and identify novel targets to prevent AD, d…
Posted May 21, 2026
Mitochondrial Function and Multiomics in Aging-related Disease: Identifying Novel Biomarkers and Causal Relationships
US · IL NIH · NAICS 541714 · grant
Mitochondria play an essential role in cellular function and impact human health through varied mechanisms, including energy metabolism, cell signaling, and apoptosis. We have previously demonstrated that mitochondrial DNA copy number (mtDN…
Posted May 21, 2026
Functional Characterization of Mitochondrial Genome Nonsense Mutations
US National Institute on Aging · grant
Mitochondria play an essential role in cellular function and impact human health through varied mechanisms, including energy metabolism, cell signaling, and apoptosis. Many aging-related diseases have a mitochondrial (MT) component, with st…
Posted May 21, 2026
Human Mitochondrial Variation and Sudden Cardiac Arrest Risk and Resuscitation
US · IL NIH · grant
Sudden cardiac arrest (SCA) is a major public health concern, accounting for up to 400,000 deaths each year. While SCA cases are heterogeneous in etiology, the most common underlying pathologic substrate is ischemic heart disease and the mo…
Posted May 21, 2026
Systematic stabilization of specific protein-protein interactions
US · IL NIH · grant
Abstract Protein-protein interactions (PPIs) are ubiquitous in biology, and their dysregulation is closely associated with diseases, from cancer to neurodegeneration to rare genetic disorders. PPIs often form complex networks that include h…
Posted May 21, 2026
Horizontal gene transfer as the source of evolutionary innovation in eukaryotes
US National Institute of General Medical Sciences · grant
PROJECT SUMMARY Horizontal gene transfer (HGT) represents a dominant force in bacterial evolution, however its role in shaping the evolutionary processes in eukaryotic genomes has been a subject of intense debate. Class Bdelloidea of the ph…
Posted May 21, 2026
Bridging Function, Connectivity, and Transcriptomics of Mouse Cortical Neurons
US National Institute of Mental Health · grant
Bridging Function, Connectivity, and Transcriptomics of Mouse Cortical Neurons The versatile and powerful functional properties of the brain are reflected in the neuronal activity patterns and computations, and their evolution over time due…
Posted May 21, 2026
Advancing Bio-Realistic Modeling via the Brain Modeling ToolKit and SONATA Data Format
US · IL NIH · grant
Advancing Bio-Realistic Modeling via the Brain Modeling ToolKit and SONATA Data Format One of the major goals of the BRAIN Initiative is to distill complex, multi-modal data into predictive frameworks via theory/modeling. As the planning do…
Posted May 21, 2026
Cell Type and Circuit Mechanisms of Non-Invasive Brain Stimulation by Sensory Entrainment
US · IL NIH · grant
Cell Type and Circuit Mechanisms of Non-Invasive Brain Stimulation by Sensory Entrainment Patterned sensory stimulation (PSS) is a non-invasive technique for manipulating brain activity and states, typically employing periodic light flicker…
Posted May 21, 2026
Summer research experiences for medical students supervised by faculty mentors
US · IL National Institutes of Health (NIH) · NAICS 541715, 611310 · grant
Since 1977, the Memorial Sloan Kettering Cancer Center (MSK) Summer Research Fellowship Program has empowered approximately 1,500 first- and second-year U.S. medical students to contribute to cutting-edge cancer research. This unique cancer…
Posted May 21, 2026
Multisite Implementation of COMPRENDO (ChildhOod Malignancy Peer REsearch NavigatiOn) to improve participation of Hispanic children in cancer clinical trials
US · IL NIH · grant
PROJECT SUMMARY Childhood cancer is the leading cause of death by disease past infancy in the U.S. While survival rates are improving, stark racial/ethnic disparities remain. Hispanic children have a significantly higher incidence of severa…
Posted May 21, 2026
Understanding the mechanisms behind complement mediated synapse elimination in neuroinflammatory disease
US · IL NIH · grant
Project Summary/Abstract The goal of this proposal is to understand how the complement component C1q impacts multiple sclerosis (MS)-related neuroinflammatory disease, and to develop a novel strategy to target complement therapeutically. MS…
Posted May 21, 2026
Neighborhood and individual environmental risk factors in early life and -omics biomarkers for kidney function trajectories across childhood and adulthood
US · IL NIH · grant
PROJECT SUMMARY/ABSTRACT Chronic kidney disease (CKD) and hypertension (HTN) are substantial public health concerns in the US and are important risk factors for other adverse outcomes including acute kidney injury and premature mortality. C…
Posted May 21, 2026
A Novel Glycosaminoglycan Mimetic Scaffold for Cartilage Repair
US · IL NIH · grant
Project Summary With the limited healing capability of articular cartilage, clinical intervention is necessary to prevent further articular cartilage damage and early onset of degenerative osteoarthritis. Current surgical procedures result…
Posted May 21, 2026
TOF-PET with high-efficiency TlCl crystals
US National Institute of Biomedical Imaging and Bioengineering · grant
Summary Time-of-flight positron emission tomography is a very effective nuclear imaging modality for the diagnosis and staging of a range of pathologies such as cancer, cardiovascular diseases, or musculoskeletal disorders. Commercial TOF-P…
Posted May 21, 2026
Visualization of native chromatin-associated complexes to elucidate chromatin regulatory mechanisms
US · IL NIH · grant
Project Summary Chromatin organizes into distinct functional domains and regulates a wide range of biological processes, including gene expression, genome integrity maintenance, and DNA accessibility. Chromatin dynamically adapts its functi…
Posted May 21, 2026
Dietary regulation of type 2 immunity and inflammation in the gut
US National Institute of Allergy and Infectious Diseases · grant
PROJECT SUMMARY Understanding the role of environmental factors including signals derived from the diet and microbiota is key to improving therapeutic and intervention strategies for gastrointestinal disorders including inflammatory bowel d…
Posted May 21, 2026
Miltenyi UltraMicroscope Blaze with Lightspeed mode for the University of North Carolina at Chapel Hill
US · NC · Chapel Hill University of North Carolina at Chapel Hill · $100-500k · grant
Project Summary/Abstract The University of North Carolina at Chapel (UNC-CH) is requesting a Miltenyi UltraMicroscope Blaze with Lightspeed mode (Blaze). This is a light-sheet microscope that can take images of large, cleared tissue samples…
Posted May 21, 2026
Data Science and Medical Image Analysis Training for Improved Health Care Delivery in Nigeria - DATICAN
US National Institute of Biomedical Imaging and Bioengineering · grant
Medical imaging allows visualisation and understanding of human tissue and internal organs, thereby providing useful information for diagnosis, treatment and patient management. There is a gross shortage of medical image analysts and data s…
Posted May 21, 2026
A Scientific Retreat to Address Ethical Challenges in Data and Sample Sharing to Advance Neurodegenerative Research
US · IL NIH · NAICS 541715 · grant
Project Summary New and emerging policies, including the NIH Data Management & Sharing Policy (NIH DMS), establish expectations that investigators share or make available data or study samples. Investigators understand and support the value…
Posted May 21, 2026
Career Development for Legally Trained Interdisciplinary Researchers in Aging and Health Sciences
US · IL NIH · grant
Project Summary The value of legally trained researchers is well established, yet there is a dearth of training and mentorship opportunities to help develop sustainable and effective research careers. First, the curriculum at major U.S. law…
Posted May 21, 2026
Identifying barriers to optimizing data sharing and accelerate discovery in Alzheimer’s disease and related dementia research
US National Institute on Aging · grant
It is a pivotal time for Alzheimer’s disease and related dementias (ADRD) research to harness data sharing and accelerate therapeutic discovery. Data sharing is important to advance research because it supports large data sets that are more…
Posted May 21, 2026
The Role of Neutrophils in Ischemia/Reperfusion Injury following Acute Stroke
US · IL NIH · grant
PROJECT SUMMARY/ABSTRACT Inflammation is the body's response to tissue damage, including brain tissue after stroke. Stroke is one of the leading causes of death and disability, affecting more that 795,000 Americans per year. A majority of …
Posted May 21, 2026
Clinical Impact of the Cefazolin Inoculum Effect
US · IL NIH · grant
ABSTRACT Staphylococcus aureus is a major human pathogen responsible for a wide range of life-threatening infections. Many of these infections are caused by methicillin-susceptible S. aureus (MSSA). MSSA represent a major burden among S. au…
Posted May 21, 2026
P01 Administrative Core
US · IL NIH · grant
ABSTRACT (Administrative Core) The clinical introduction of antibiotics in 1930s-40s represented a major medical breakthrough enabling many advances in modern medicine, agriculture and industrial practice. Unfortunately, the rise of antibio…
Posted May 21, 2026