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20,086 contracts

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Showing 25 / 20086 · page 137/804
Strategies to Achieve Viral Suppression for Youth with HIV (The SAVVY Study)
US National Institute of Mental Health · grant
PROJECT SUMMARY Adolescents and young adults (AHIV) ages 12-30 years have disproportionately poorer outcomes across the HIV care continuum, including lower rates of adherence to oral ART (oART) and viral suppression (VS) than older adults, …
Posted May 21, 2026
Sustainability determinants of an intervention to identify clinical deterioration and improve childhood cancer survival in low-resource hospitals
US National Cancer Institute · grant
PROJECT SUMMARY/ABSTRACT Background and Goal. More than 90% of children with cancer live in low-resourced settings, where survival is only 20%. Sustainable evidence-based (EB) interventions yielding ongoing beneficial patient outcomes is cr…
Posted May 21, 2026
Tumor Microenvironment and Metastasis Program
US National Cancer Institute · grant
TUMOR MICROENVIRONMENT AND METASTASIS PROGRAM - PROJECT SUMMARY/ABSTRACT The Tumor Microenvironment and Metastasis (TMM) Program is focused on investigating the genetic, epigenetic, biochemical, microenvironmental, and developmental pathwa…
Posted May 21, 2026
Functional Determinants of Metastatic Dormancy
US National Cancer Institute · grant
SUMMARY. The majority of cancer patients die of metastases originating from disseminated cancer cells (DCCs), years and decades after treatment. This has been linked to the ability of DCCs to survive in a dormant state and evade therapies. …
Posted May 21, 2026
Investigating disseminated cancer cell clonal cooperation and immune control in dormancy and metastasis
US National Cancer Institute · grant
SUMMARY. We revealed that cancer cells can disseminate from early stages of cancer progression and after variable periods of dormancy they go on to form metastasis. Knowledge about how early DCCs (eDCCs) shape metastatic progression, how th…
Posted May 21, 2026
Effects of Ventral Tegmental Area Dopamine Neurons GABA-B Receptor Deletion on Cue-Evoked Relapse and Aversion-Resistant Drinking
US National Institute on Alcohol Abuse and Alcoholism · grant
RESEARCH SUMMARY Alcohol use disorder (AUD) is characterized by the inability to control or stop the use of alcohol, even in the face of negative consequences or after long-term abstinence. Thus, it is important to understand the risk facto…
Posted May 21, 2026
Flicker photophobia as an experience of inefficient coding
US National Eye Institute · grant
Project Summary A canonical feature of migraine is visual discomfort (i.e., “photophobia”), with particular sensitivity to flicker (time-varying modulations of light). We lack a mechanistic understanding of this symptom generally, and specifi…
Posted May 21, 2026
Research Training Program in Disease-Oriented Neuroscience (R25)
US National Institute of Neurological Disorders and Stroke · grant
SUMMARY This Research Training Program in Disease Oriented Neuroscience is designed to facilitate the transition between graduate training and a research-based career in neurology and neurosurgery. R25 program trainees receive career mentor…
Posted May 21, 2026
Mechanisms of response and resistance to KRAS inhibition in pancreatic cancer
US National Cancer Institute · grant
PROJECT SUMMARY/ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is a devastating cancer, with a five-year survival of only 10%. There is an urgent need to develop new therapeutic strategies for this disease. Oncogenic KRAS mutations occur …
Posted May 21, 2026
Oxylipin Signaling in Congenital Heart Disease
US National Heart Lung and Blood Institute · grant
Project summary Congenital heart defects (CHD) constitute the most common type of congenital defect in humans, however the causes for CHD in most cases are unknown. Lipoxygenase-derived oxylipins are a complex and poorly characterized class…
Posted May 21, 2026
Tissue Perfusion Pressure for Improved Management of Circulatory Shock
US National Heart Lung and Blood Institute · grant
Circulatory shock is one of the most common reasons for admission to an intensive care unit (ICU) and results from inadequate blood pressure and blood flow to support organ function. Causes of circulatory shock include heart failure, sepsis…
Posted May 21, 2026
Early response to radiotherapy and immunotherapy in rectal cancer: an integrated molecular, cellular, and spatial approach
US National Cancer Institute · grant
Project Abstract With increased incidence in young populations and ~65% three-year survival of high-risk locally advanced rec- tal cancer, innovative approaches to improve outcomes is imperative. Neoadjuvant therapy with radiation (RT) and …
Posted May 21, 2026
Research Capacity Core
US National Institute on Minority Health and Health Disparities · grant
ABSTRACT In recent years the BBRC has been at the forefront of an expansion in Hispanic Health Disparities research at UTEP, this has led to a new vision involving the reorganization of the Research Capacity Core (RCC) to better serve th…
Posted May 21, 2026
Characterization of novel pyrazole compounds with potent anti-cancer activity
US National Institute of General Medical Sciences · grant
Breast cancer is the most frequently diagnosed tumor type and a common cause of cancer-related deaths in women worldwide. In the US, Triple Negative Breast Cancer (TNBC) continues to be a deadly disease. Since TNBC is an aggressive subtype …
Posted May 21, 2026
Restoring Ocrl1 function in Lowe Syndrome and Dent-2 disease
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
Lowe Syndrome (LS) is a disease caused by mutations in the OCRL1 gene that unfortunately leads to the early death of affected children and has no cure. However, this project aims to change such scenario. Further, since OCRL1 mutations also …
Posted May 21, 2026
Colombia-U.S. Fogarty training program on the impact of emerging zoonotic and vector-borne diseases in acute undifferentiated febrile illnesses
US John E. Fogarty International Center for Advanced Study in the Health Sciences · grant
Abstract Non-malarial acute undifferentiated febrile illnesses (AUFIs) are significant causes of morbidity and mortality in Latin America, and the incidence of dengue-like illness has increased dramatically in recent years. As in most low-a…
Posted May 21, 2026
Metabolic Modulation Suppresses Survival Signals in B-Cell Lymphoma
US Veterans Affairs · grant
Significance to VA : Metabolic remodeling is integral to cancer biology. The discovery of somatic mutations in genes encoding metabolic enzymes provided insights into how subverting metabolism promotes cancer. These studies also uncovered …
Posted May 21, 2026
BLRD Research Career Scientist Award Application
US Veterans Affairs · grant
The overarching objective of the Aguiar laboratory is to improve our understanding of cancer biology, in particular the molecular and cellular basis of B cell lymphomas development and progression with the intent of translating these discov…
Posted May 21, 2026
Post-Translational Control of TET Function in Lymphoma
US Veterans Affairs · grant
TET DNA hydroxylases are alpha-ketoglutarate (αKG)-dependent enzymes that catalyze the oxidation of 5mC to 5-hydroxymethylcytosine (5hmC), thus promoting DNA demethylation. Mapping of 5hmC marks at single base resolution demonstrated that t…
Posted May 21, 2026
Non-B DNA structure discovery and function assessment using nanopore translocation times
US National Human Genome Research Institute · grant
Abstract The canonical double helical structure of DNA (B-DNA) allows for stability and high-fidelity replication, but emerging evidence suggests an increasingly important role for non-canonical (or non-B) DNA structures in the cell. Non-B …
Posted May 21, 2026
The Illinois Kids Development Study ECHO Pregnancy and Pediatric Cohort
US NIH Office of the Director · grant
This is a competitive renewal application (1) to continue to follow children in the Illinois Kids Development Study (IKIDS) who are participants in ECHO, and (2) to continue recruiting new pregnant women into the IKIDS ECHO cohort. We will …
Posted May 21, 2026
High-throughput analysis of dynamics of antibody responses against defined epitopes: prioritization of diagnostic and prognostic markers for Chagas disease
US National Institute of Allergy and Infectious Diseases · grant
1 PROJECT SUMMARY / ABSTRACT 2 3 Trypanosoma cruzi is a parasite responsible for an important human disease, Chagas Disease, which 4 is endemic in the Americas. The parasite is transmitted by the bite of an insect, or by blood transfusio…
Posted May 21, 2026
Engineering dendritic cells to target islet antigen to pro-tolerogenic subsets for prevention and treatment of Type 1 Diabetes
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
Project Summary Although induction of antigen-specific tolerance by means of targeting such antigens to dendritic cells (DCs) has been reported in multiple pre-clinical studies, there are currently no effective approaches using DCs in the c…
Posted May 21, 2026
Elucidating and targeting beta-cell senescence and its SASP
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
Abstract This proposal seeks to elucidate the mechanisms of β-cell senescence, an aging hallmark, as a contributor to type 2 diabetes (T2D) and identify optimal therapeutic targets. Pancreatic insulin secreting β-cells, crucial to glucose h…
Posted May 21, 2026
Smartphone-based wound infection screener and care recommender by combining thermal images and photographs using deep learning methods
US National Institute of Biomedical Imaging and Bioengineering · grant
I. PROJECT SUMMARY: Smartphone-based wound infection risk screener and care recommender by combining thermal images and photographs using deep learning methods Chronic wounds, which affect 6.5 million patients in the US12 severely affect th…
Posted May 21, 2026