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Showing 25 / 20086 · page 16/804
A life course perspective on gut microbiome aging and health in a non-human primate model
US · IL NIH · NAICS 541714 · grant
PROJECT SUMMARY The gut microbiome has repeatedly been linked to major diseases of aging, including frailty, osteoporosis, and diabetes. However, after more than a decade of searching, there is still no consensus on which microbial species…
Posted May 21, 2026
Developing insertable cardiac monitors to assess social and environmental effects on the autonomic stress response in a nonhuman primate model of aging
US National Institute on Aging · grant
Project Summary The long reach of early life remains one of the most enduring puzzles in human health. From famine to poverty and neglect, adverse early life experiences lead to higher mortality and elevated risk for obesity, diabetes, and…
Posted May 21, 2026
MSPP Application
US · IL National Institutes of Health (NIH) · grant
NOT APPLICABLE no Abstract
Posted May 21, 2026
Epigenetic and Transcriptional Functions of Nuclear Receptors and Chromatin Remodeling Proteins in Stem and Cancer Cells
US · IL NIEHS · grant
The elegant organization of nucleic acids, predominantly DNA, into chromatin serves essential structural and regulatory roles in eukaryotic cells. This beautiful architecture allows for an expansion of the underlying genetic information by …
Posted May 21, 2026
Penalized mixture cure models for identifying genomic features associated with outcome in acute myeloid leukemia
US National Library of Medicine · grant
Molecular features associated with time-to-event outcomes, such as overall or disease-free survival, may be prognostically relevant or potential therapeutic targets. Therefore, analyzing data from high-throughput genomic assays with clinica…
Posted May 21, 2026
Genetic Contributors to White Matter Microstructure in Aging and Alzheimer’s Disease
US National Institute on Aging · grant
PROJECT SUMMARY While reductions in medial temporal lobe (MTL) white matter tract microstructure have been suggested to have a central role in longitudinal cognitive decline in aging and Alzheimer’s disease (AD), it is unknown what genetic …
Posted May 21, 2026
Small Molecule Therapeutics for Sickle Cell Anemia
US · IL NIH · grant
Project Summary Sickle Cell Disease (SCD) is a common genetic condition that affects approximately 100,000 people of African heritage in the US, and more than 4 million worldwide. The disease is caused by a single amino acid substitution in…
Posted May 21, 2026
NICHD: SERVICE: CCTN LB PHASE 2B CLINICAL TRIAL: NON-SEVERABLE
US Eunice Kennedy Shriver National Institute of Child Health and Human Development · grant
The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) serves as the lead federal agency advancing research in fertility optimization. Within NICHD, the Contraceptive Development Program (CDP) under the …
Posted May 21, 2026
CCTN-CONTRACEPTIVE DEVELOPMENT PROGRAM – CORE FUNCTION ACTIVITIES FOR SITES OF FEMALE CONTRACEPTIVE STUDIES - EAST VA
US Eunice Kennedy Shriver National Institute of Child Health and Human Development · grant
There is a demand for new methods of contraception that can provide effective protection against unintended pregnancy as well as reduce the risk of venous thromboembolism (VTE), particularly for obese women. The mission of the Contraceptive…
Posted May 21, 2026
Structural consequences of PKC-dependent phosphorylation of Kv7.2
US · IL NIH · grant
Project Summary M channels are critical for regulating the excitability of neurons. Dysfunction of M channel activity can cause epilepsy. While M channels have been intensely studied, the interplay of several G-protein-regulated signaling …
Posted May 21, 2026
Exploratory study of the efficacy and feasibility of the Aphasia: Nurturing Connections, Honoring Ongoing Relationships (ANCHOR) program
US · IL NIH · grant
Abstract Many people with aphasia (PwA) lose contact with the majority of their friends in the months following the onset of this disorder. Losing friendships and the ensuing social isolation place a large number of PwA at risk for reduced …
Posted May 21, 2026
Evaluation of Long Acting Injectable (LAI) and Teen clubs in adolescents (ATTUNE)
US · IL NIH · grant
PROJECT SUMMARY Significance: South Africa has the highest number of adolescents living with HIV in the world with increasing numbers expected to continue. However, adolescents living with HIV in South Africa have poor outcomes along each s…
Posted May 21, 2026
Randomized Trial of a Novel Approach to Addressing Fear of Progression in Advanced Cancer
US National Cancer Institute · grant
ABSTRACT Precision oncology has led to a growing population of adults with advanced cancer living increasingly longer lives in the face of profound uncertainty about the future, with over half reporting moderate to high fear of cancer progr…
Posted May 21, 2026
Factors of Resilience to Alzheimers Disease and Related Dementias among Latinx: The Role of Bilingualism
US National Institute on Aging · grant
Project Summary/Abstract As the population ages, Latinx communities, families, and healthcare systems will be confronted by the growing crisis of Alzheimer's disease and related dementias (ADRD). Identifying factors that confer resilience t…
Posted May 21, 2026
Mammary Epithelium Permeability, Lactation Outcomes, and Infant Health
US Eunice Kennedy Shriver National Institute of Child Health and Human Development · grant
Project Summary/Abstract Human milk provides significant health benefits for infants. Beyond nutrients, breastmilk contains antibodies for immunity, growth factors associated with gut epithelial maturation, bacteria for establishment of the…
Posted May 21, 2026
Unraveling how Lipophilic Modulators Alter pLGIC Function via Interactions with the M4 Transmembrane Helix
US National Institute of General Medical Sciences · grant
Project Summary/Abstract Dr. Mark Arcario is a cardiothoracic anesthesiologist whose long-term goal is to be an independent physician- scientist studying molecular mechanisms of allostery in ion channels. His research background is in compu…
Posted May 21, 2026
The Virginia Advancing Cancer Control Engaged Research through Transformative Solutions Center
US National Institutes of Health (NIH) · grant
In the US, individuals and families living in poverty are placed at increased risk for cancer. Living in an under-resourced environment and having limited access to affordable and healthy food and opportunities for physical activity play a …
Posted May 21, 2026
PRIMING THE PUMP: TRAINING PHYSICIAN-SCIENTISTS IN TRANSLATIONAL PSYCHIATRY
US NIH · grant
PROJECT SUMMARY: This proposal is to continue our highly successful research track program (Columbia RTP) which aims to recruit and retain both MD/PhDs and other medical graduates with substantial research backgrounds into translational res…
Posted May 21, 2026
Humanization of a Notch 3 Agonist Antibody for Pre-Clinical Development of a CADASIL Treatment
US · IL NIH · NAICS 541714 · grant
PROJECT SUMMARY Notch 3 mutations are the cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a small vessel disease characterized by stroke and vascular cognitive impairment. Trans…
Posted May 21, 2026
Human Genetic risk factors for Disseminated Coccidioidomycosis (DCM)
US National Institute of Allergy and Infectious Diseases · grant
Scientific Project 3: Human Genetic Risk Factors for Disseminated Coccidioidomycosis (DCM) ABSTRACT This project will focus on elucidating human host genetic risk variants that predispose individuals to DCM. For the past 80 years, epidemiol…
Posted May 21, 2026
Training Grant in Genomic Analysis and Interpretation
US · CA · Los Angeles National Institutes of Health (NIH) · NAICS 611310 · grant
Project Summary/Abstract Modern genome projects have dramatically increased the amount of genetic and associated biomedical data available to researchers. Turning the flood of data generated by rapidly evolving genomic technologies and othe…
Posted May 21, 2026
Improving outcomes and reducing disparities through integrated primary care-specialty care implementation of the CDC Pediatric Mild TBI Guideline
US National Center for Injury Prevention and Control · grant
Mild traumatic brain injury (mTBI) is a common injury in childhood with the potential to have a substantial impact on function in the school and sports setting. Early recognition, followed by up-to-date mTBI care, has been demonstrated to i…
Posted May 21, 2026
UNITED: Understanding neurocognitive outcomes in Type 1 diabetes: Modifiable risk and protective factors in diverse youth
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
PROJECT SUMMARY Growing evidence suggests that individuals with Type 1 diabetes mellitus (T1D) are at risk for cognitive dysfunction over time, with approximately 28% of middle-aged adults with T1D and 48% of older adults with T1D meeting c…
Posted May 21, 2026
Optimizing feedback-based learning in children with developmentallanguage disorder.
US · IL NIH · grant
ABSTRACT This project aims to optimize a critical but understudied ingredient of language intervention provided to children with developmental language disorder (DLD) – feedback. The project is designed to bridge the gap between previous fi…
Posted May 21, 2026
Genes underlying reproductive behavior physiology and neuronal development
US · IL National Institutes of Health (NIH) / National Institute of General Medical Sciences (NIGMS) · grant
Project Summary/Abstract To understand mental health and disease, we need to understand the function of the brain at the level of genes, gene regulatory networks, neurons, circuit structure, and physiology. Drosophila has emerged as one of …
Posted May 21, 2026