Live opportunities

20,086 contracts

🏛Federal 🗽State 🏞County 🏙City 🎓Schools 🚇Districts 📚Universities
Showing 25 / 20086 · page 17/804
Project 1: Therapeutic Gene Editing for Spinal Muscular Atrophy (Trailblazer)
US · IL NIH · grant
PROJECT SUMMARY PROJECT 1 (SMA) Spinal Muscular Atrophy (SMA) is a progressive motor neuron disease (MND) and the leading genetic cause of infant mortality across all ethnic groups. SMA is caused by the homozygous loss of the essential surv…
Posted May 21, 2026
Precision Base Editing for the Treatment of Motor Neuron Diseases
US National Institute of Neurological Disorders and Stroke · grant
Motor neuron diseases (MNDs) such as spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS) are a class of progressive neurodegeneration disorders, often caused by minor genetic abnormalities to which motor neurons are partic…
Posted May 21, 2026
Terahertz time-domain spectroscopic imaging of cornea for three dimensional mapping of hydration gradients
US National Eye Institute · grant
Project Summary There are several ophthalmological diseases and ailments that perturb the normal water content or hydration levels of the corneal layer. Among these, Fuchs’ dystrophy, keratoconus, and elevated intraocular pressure (IOP) - a…
Posted May 21, 2026
Developing a Community Health Training Program for Population Health Scholars
US · IL NIH · NAICS 611430 · grant
This project will: 1) Create an educational curriculum that examines the following components to optimize the health of women and their families; 2) Pilot test the educational curriculum to iterate and refine course content and supplementar…
Posted May 21, 2026
Optimizing the HIV Prevention and Care Continua in the United States
US National Institute of Allergy and Infectious Diseases · grant
Subgroups within the House and Ballroom Community (HBC) account for at least half of all new HIV infections in the United States (U.S.). At the same time there is a significant disparity in knowledge of, access to and uptake of pre-exposure…
Posted May 21, 2026
Advancing Gender and Health Justice Research and Education
US · IL NIH · grant
Multiple epidemics converge in the lived experiences of those at multiple intersecting minoritized social positions. People who identify as women experience gender-based violence, are vulnerable to HIV transmission, and face grave structura…
Posted May 21, 2026
Evolutionary Analysis and Comparative Genomics of Protein Superfamilies
US · IL National Institutes of Health (NIH) · NAICS 541714 · grant
The systematic analysis and discovery of biological conflict systems have been a major focus of research in the Aravind lab. Biological replicators, from genes within a genome to whole organisms, are locked in conflicts. Comparative genomic…
Posted May 21, 2026
Molecular mechanism of the piRNA biogenesis
US National Institute of General Medical Sciences · grant
Project title: Molecular mechanism of piRNA biogenesis Project summary Non-coding RNAs have diverse functions in eukaryotic cells. Use of these non-coding RNAs in therapeutic approaches is a promising but rather unexplored direction in bio…
Posted May 21, 2026
Cortical dystonia of prematurity
US · IL NIH · grant
PROJECT SUMMARY Preterm birth is the most common cause of cerebral palsy (CP) in the US and, consequently, the most common cause of childhood dystonia, a disabling condition affecting 2 of every 1000 Americans. Despite its high prevalence, …
Posted May 21, 2026
Modulation of striatal cholinergic interneuron activity to prevent dystonic cerebral palsy
US National Institute of Neurological Disorders and Stroke · grant
PROJECT SUMMARY This proposal will determine whether increasing striatal cholinergic interneuron (ChI) activity in the developing mouse brain can prevent dystonia following neonatal brain injury . Dystonic cerebral palsy (CP) due to neonata…
Posted May 21, 2026
Interplay Between Macrophages, Lipid Oxidation and the Nrf2/HO-1 Axis in the Cardiometabolic Toxicity Induced by Ultrafine Particles
US National Institute of Environmental Health Sciences · grant
PROJECT SUMMARY/ABSTRACT Cumulative epidemiological and experimental evidence have shown that exposure to air pollutants leads to increased cardiovascular morbidity and mortality. These associations have been mostly ascribed to the particul…
Posted May 21, 2026
Dissecting the Role of Arachidonic Acid Metabolic Pathways Involved in Resolution Versus Progression of PM-Induced Cardiometabolic Toxicity
US National Institute of Environmental Health Sciences · grant
ABSTRACT Epidemiological and experimental data have shown that chronic exposure to ambient particulate matter (PM) leads to exacerbation of atherosclerosis, and increased cardiovascular morbidity and mortality. We have shown that mouse expo…
Posted May 21, 2026
Project 3: Integration of mammographic AI, clinical, and genomics information to improve breast cancer subtype- specific risk-based screening and prevention
US · IL National Institutes of Health · NAICS 541715 · grant
PROJECT 3: Summary The ongoing WISDOM risk-based breast cancer screening and prevention trial, which started in 2016, is a ground-breaking comparative effectiveness study to establish whether personalized breast cancer screening based on in…
Posted May 21, 2026
Role of cardiac clock misalignment in promoting arrhythmias in swine and donor human hearts
US · IL NIH · NAICS 541714 · grant
PROJECT ABSTRACT Sudden cardiac arrest (SCA) due to malignant ventricular arrhythmias remains a major cause of mortality in the US. While the majority of SCA patients have significant coronary artery disease (CAD), nearly one in three patie…
Posted May 21, 2026
Role of epicardial adiposity as a local mediator of VT/VF dynamics in donor human hearts
US National Heart Lung and Blood Institute · grant
Project Summary: Ventricular tachyarrhythmias are responsible for 300,000 sudden cardiac deaths a year in the US. The mechanisms underlying these arrhythmias in the majority of cases are ventricular tachycardia (VT) and/or ventricular fibri…
Posted May 21, 2026
University of Minnesota Summer Research in Neuroscience
US NIH RePORTER · grant
PROJECT DESCRIPTION Disorders of the nervous system are becoming more prevalent in our society, especially considering the growing elderly population who are more vulnerable to neurodysregulation. To meet the challenge of developing new and…
Posted May 21, 2026
Branched chain amino acids in heart failure
US · IL NIH · grant
SUMMARY Heart failure (HF) is a leading cause of death worldwide, and the leading cause of hospital admissions in patients over 65 in the US. Novel therapies, addressing novel pathways, are direly needed. The role of metabolism in cardiac p…
Posted May 21, 2026
Understanding how SGLT2 inhibitors protect from heart failure
US National Heart Lung and Blood Institute · grant
SUMMARY Heart failure is a leading cause of death worldwide, and the leading cause of hospital admissions in patients over 65 in the US. The role of metabolism in cardiac pathology has long been of interest, but no therapies that target car…
Posted May 21, 2026
Comprehensive quantification of fuel use in cold-induced thermogenesis in vivo
US · IL NIH · grant
SUMMARY Cold-induced thermogenesis (CIT) allows endotherms, including mammals, to maintain body temperature at ~37oC despite sometimes much colder ambient temperature. Pharmaceutical activation of CIT is being investigated by many groups as…
Posted May 21, 2026
Acetate and Endothelial Pathobiology
US · IL NIH RePORTER · grant
Chronic vascular inflammation is a hallmark of atherosclerosis, pulmonary arterial hypertension (PAH) and related conditions. It is also one of the principal causes of endothelial- to-mesenchymal transition (EndMT). We have recently demonst…
Posted May 21, 2026
Keeping fat out of muscle - Role of Branched Amino AcidsAmino Acids in Insulin Resistance
US · IL NIH · grant
Abstract Type 2 Diabetes Mellitus (T2DM) and insulin resistance (IR) are major contributors to global cardiovascular morbidity and mortality. The parent R01 grant uncovered that branched-chain amino acid (BCAA) catabolism promotes glucose d…
Posted May 21, 2026
Selective mTORC1 inhibition to prevent and treat NAFLD and NASH
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
As many as 100 million people in the US have non-alcoholic fatty liver disease (NAFLD), which can lead to hepatic injury and fibrosis, characteristics of non-alcoholic steatohepatitis (NASH), and in turn can progress to cirrhosis and hepato…
Posted May 21, 2026
Impact of Anticholinergic Medication on Salivary Function; Exploring Potential Genetic Markers for Dry Mouth
US National Institute of Dental and Craniofacial Research · grant
The growing medication use in all ages led to the fact that 20% of the US adult population take five or more drugs (polypharmacy). Over 500 medications commonly prescribed in polypharmacy (e.g., antidepressants, urinary antispasmodics, and …
Posted May 21, 2026
Clinical Core
US · IL NIH · grant
ABSTRACT – Clinical Core This goals of this research project are to advance our understanding of the pathophysiologic mechanisms contributing to cognitive and affective impairments in NPSLE. The Clinical Core will provide the necessary infr…
Posted May 21, 2026
Regulation of translation initiation by the epitranscriptome
US · IL NIH RePORTER · $1-5M · grant
Project Summary/Abstract My research program investigates how the epitranscriptome regulates protein synthesis and how this interplay affects cell fate decisions under normal homeostasis and stress conditions. The epitranscriptome is the co…
Posted May 21, 2026