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Showing 25 / 20086 · page 18/804
Understanding A Molecular Cascade That Drives Neutrophil Mediated Pathology In Arthritis
US National Institute of Allergy and Infectious Diseases · grant
UNDERSTANDING A MOLECULAR CASCADE THAT DRIVES NEUTROPHIL MEDIATED PATHOLOGY IN ARTHRITIS Rheumatoid arthritis (RA) is a frequent chronic disease of the synovial joints characterized by painful loss of mobility due to unrestrained inflammat…
Posted May 21, 2026
Outreach, Recruitment, and Engagement (ORE) Core
US National Institute on Aging · grant
REVISED ABSTRACT: Outreach, Recruitment, and Engagement Core: Project Summary –2P30AG066530-06 (5769) The overall objective of the Outreach, Recruitment and Engagement Core (ORE Core) is to serve as the primary bilingual and bicultural …
Posted May 21, 2026
CRISPR-based transistors for high throughput multiplexed monitoring of CRISPR-based editing efficiency for Sickle cell disease
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY/ABSTRACT SCD is a heritable disease, which affects a patient's red blood cells (RBCs). This monogenic disorder is caused by a single nucleotide polymorphism (SNP) within the HBB gene. Despite progress in the treatment of SCD…
Posted May 21, 2026
PHARMACEUTICS FORMULATION/CHEMISTRY MANUFACTURING AND CONTROL CONSULTING SERVICES FOR SMALL MOLECULES AND/OR BIOLOGICS
US National Institute on Drug Abuse · grant
Pharmaceutics / Formulation / CMC Pharmaceutics / Formulation/ CMC consultants will be expected to provide executive (senior scientific)-level Pharmaceutics / Formulation/ CMC expertise and contribute feedback and guidance on projects to t…
Posted May 21, 2026
MEDICINAL CHEMISTRY CONSULTING SERVICES
US · IL NIH · grant
This study is part of the NIH’s Helping to End Addiction Long-term (HEAL) initiative to speed scientific solutions to understand the basis of pain and enhance clinical pain management; pain The medicinal chemistry Consultant will be expecte…
Posted May 21, 2026
Pain in the Elderly: Role of Hyperalgesic Priming
US · IL NIH · grant
Abstract Management of pain is a significant problem in the elderly, with the burden of chronic pain heavily tilted toward older adults. The high incidence of pain in the elderly has been suggested to be related to an increase in stress and…
Posted May 21, 2026
Naive CD8 T cell functional heterogeneity
US · IL NIH · grant
Project Summary There has been considerable progress in identifying subsets in effector, memory, and exhausted CD8 T cells, and our understanding of the role of each subset in response to infection has greatly improved. However, much less i…
Posted May 21, 2026
Cognitive challenge to reveal systemic neurophysiology biomarkers in pre-symptomatic Alzheimer’s disease
US · IL NIH · grant
The burden on Alzheimer’s disease (AD) is growing due to longer life span and lack of effective treatment. The knowledge gap exists for early detection and prediction of symptom onset. AD pathology (amyloid/tau) and synaptic dysfunction pre…
Posted May 21, 2026
The effect of circadian rhythm disruptions on the angiogenic response to hypoperfusion in the AD brain
US National Institute on Aging · grant
PROJECT SUMMARY/ABSTRACT Although the pathophysiology of Alzheimer’s Disease (AD) is complex and multifactorial, vascular comorbidities and cerebrovascular insufficiency occur in almost two-thirds of AD patients. However, how cerebrovascula…
Posted May 21, 2026
Cell Cycle Control Of Arterial-Venous Specification Within the Developing Embryo
US · IL NIH · grant
Project Summary: The blood vascular circulatory system is composed of arterial, venous, and capillary vessels, which work together to facilitate the efficient exchange of gasses, nutrients, and waste from all tissues, while regulating bloo…
Posted May 21, 2026
NMDOH Scientific Laboratory Division Retail Meat Surveillance Program
US Food and Drug Administration · grant
Project Summary Antimicrobial resistance is one of our most serious health threats. Antimicrobial use in food animals can lead to antibiotic-resistant infections in humans. Infections from resistant bacteria are now too common, and some pat…
Posted May 21, 2026
Population genomics in peripartum cardiomyopathy
US · IL NIH · NAICS 541714 · grant
PROJECT SUMMARY Peripartum cardiomyopathy (PPCM) is a form of heart failure characterized by left ventricular dysfunction that occurs during late pregnancy or shortly after delivery. This condition causes a sudden weakening of the heart mu…
Posted May 21, 2026
Population Assessments of Aggregate Genetic Risk for Dilated Cardiomyopathy
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY Candidate. Krishna G. Aragam, MD MS is a board-certified physician in internal medicine and cardiology at Massachusetts General Hospital (MGH), an Instructor in Medicine at Harvard Medical School (HMS), and an affiliated res…
Posted May 21, 2026
Structural and Functional Studies of Cell-Adhesion Receptors
US · IL NIH · grant
Project Abstract Cellular communication is essential for the development of all multicellular organisms, and is a key phenomenon that is disrupted in many human diseases. Cell-surface receptors mediate cellular communication and are the tar…
Posted May 21, 2026
Integrated Therapies for Alcohol use in Alcohol-associated Liver Disease (ITAALD) - Virginia Commonwealth University
US · VA National Institutes of Health · grant
Severe alcohol-associated hepatitis (sAH) has high short-term mortality, yet it currently has no FDA-approved therapy. Although return to drinking impacts quality of life and mortality in these patients, available pharmacological treatments…
Posted May 21, 2026
Cardiometabolic Health and Epigenetic Aging Across the Life Course Among Hispanic/Latino Immigrant Groups in the United States
US · IL NIH · grant
PROJECT SUMMARY (ABSTRACT) Hispanic/Latino populations in the United States (U.S.) carry a disproportionate burden of poor cardiometabolic health outcomes, with higher rates of obesity, diabetes, and hypercholesterolemia than non-Hispanic W…
Posted May 21, 2026
Kansas Center for Metabolism and Obesity REsearch (KC-MORE) - Cells, Tissues, Bioanalysis and Biostatistics Core
US National Institute of General Medical Sciences · grant
CELLS, TISSUES, BIOANALYSIS AND BIOSTATISTICS CORE: PROJECT SUMMARY Adding a translational component to confirm ideas generated using in vitro and animal models is a vital part of biomedical research. This is especially critical for a multi…
Posted May 21, 2026
Degradomics of proteolytic mechanisms in post-traumatic osteoarthritis
US · IL NIH · grant
Osteoarthritis (OA) is usually diagnosed when joint damage is well under way. Its early detection and treatment continue to be elusive, requiring greater knowledge of pathogenic processes and potential drug targets active early in the disea…
Posted May 21, 2026
Investigating the regulation of T cell-mediated autoimmunity in type 1 diabetes by microRNA146a
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
PROJECT SUMMARY/ABSTRACT Type 1 diabetes (T1D) is a chronic autoimmune disease that results in destruction of pancreatic islet beta cells by autoreactive T lymphocytes. T1D is the most common form of diabetes in children less than 15 years …
Posted May 21, 2026
Novel Over-the-Scope Platform for Control of Variceal Bleeding
US · IL NIH · grant
Abstract Upper gastrointestinal (UGI) bleeding from variceal hemorrhage marks a major turning point in the life of a patient with cirrhosis. Up to 20% of these patients will die from the event. A major shortcoming in the treatment of UGI va…
Posted May 21, 2026
How NTS NPY neurons alter NTS circuitry to promote food intake
US · IL NIH · grant
Obesity is a major health problem in the United States and a leading contributor to cardiovascular disease, diabetes mellitus and stroke. One region essential for the control of meal size is the nucleus of the solitary tract (NTS) in the br…
Posted May 21, 2026
The Enteric Glia as a Possible Target for Symptom Relief in Endometriosis
US · IL NIH · grant
Endometriosis, a chronic painful gynecological disorder defined as the presence of endometrial glands and stroma outside the endometrial cavity, is characterized by peritoneal inflammation, fibrosis, adhesions, and ovarian cysts. Women with…
Posted May 21, 2026
Research Education Core
US National Cancer Institute · grant
The Research Education Core (REC) of the Ponce Health Sciences University and Moffitt Cancer Center Partnership has built an educational program that supports participants across the career continuum, preparing them for basic or clinical …
Posted May 21, 2026
Molecular Mechanisms of Non-muscle Myosin II Contractility
US · IL NIH RePORTER · grant
PROJECT SUMMARY/ABSTRACT Non-muscle myosin II (NMII) contractility is critical to number cellular processes from development to disease. NMII is an ATP-dependent molecular motor that functions as a dimer composed of two heavy chains, which …
Posted May 21, 2026
PEG Hydrogels to Investigate the Role of Vasa Vasorum Angiogenesis in Tissue Engineered Vascular Grafts
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY Tissue engineered vascular grafts (TEVGs) are a promising alternative to autologous tissues, yet none have been clinically approved for small-diameter revascularization due to pathological remodeling. Our lab previously sho…
Posted May 21, 2026