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Showing 25 / 20086 · page 19/804
Tracing the Impact of Evolving Environmental Exposure to Tobacco, Cannabis, and Nicotine Smoke and Vapor Emissions on Children's Mental Health Symptom Trajectories
US · IL NIH · grant
PROJECT SUMMARY Background: In recent years, while combustible cigarette smoking has decreased, use and co-use of electronic nicotine delivery systems (ENDS) and cannabis smoking has increased among adults of reproductive age. This suggests…
Posted May 21, 2026
Embrace Genomics
US · IL National Institutes of Health (NIH) · NAICS 611430, 611710 · grant
Genetics and genomics have become increasingly important in research and medicine. The understanding of the genetic contribution to disease is quickly expanding from rare disease to common disease, making genetics and genomics relevant to a…
Posted May 21, 2026
New low cost technology for early detection of ear disorders
US · IL NIH · NAICS 339112, 541715 · grant
Most conductive hearing loss stems from pathologies affecting the tympanic membrane (TM), including perforations, retraction pockets, cholesteatoma, atelectasis, and tympanosclerosis. These conditions often go undetected until significant h…
Posted May 21, 2026
Development of a high performance reduced cost OCT Otoscope
US · IL NIH · NAICS 339112 · grant
The method physicians use to examine the tympanic membrane (TM) and middle ear (ME) in clinical settings has remained largely unchanged for the past 150 years. Typically, a speculum is inserted into the ear canal, with the physician using a…
Posted May 21, 2026
Role of glucagon-like peptide-1 signaling in mediating sensory-specific satiety
US · IL NIH · NAICS 541715 · grant
PROJECT SUMMARY/ABSTRACT Despite its critical role in meal cessation, the neuroendocrine mechanisms underlying sensory-specific satiety (SSS) are largely unknown. SSS is the transient reduction in motivation and pleasantness for a recently…
Posted May 21, 2026
Liquid biopsy approaches to inform neuroblastoma prognosis and disease monitoring
US · IL NIH · NAICS 541714 · grant
Abstract Fewer than half of all children with high-risk neuroblastoma become long-term survivors. Currently, it is not possible to predict if a child will be cured with standard therapy or is destined to relapse. Furthermore, standard clini…
Posted May 21, 2026
Meaning-Centered Psychotherapy to Meet Palliative Care Needs of Cancer Caregivers
US National Cancer Institute · grant
PROJECT SUMMARY In 2020, 53 million people in the U.S. served as family caregivers, the partners, relatives, and friends who provide assistance (i.e., physical, emotional) to patients with often life-threatening, incurable illnesses. Caregi…
Posted May 21, 2026
TASK ORDER 1 - OCR PROJECT MANAGEMENT, DSMB AND CROMS-RELATED SUPPORT
US · IL NIH RePORTER · grant
Alzheimer's disease
Posted May 21, 2026
Tumor Suppressor Protein, p53
US · IL NIH · grant
The p53 tumor suppressor protein is a key component of the cellular response to stress. It is a homo-tetrameric, sequence-specific transcription factor activated by DNA damage, hypoxia, heat shock, and other types of stress and regulates DN…
Posted May 21, 2026
Regulation and Function of WIP1 Phosphatase and its Role in Tumor Cells
US · IL NIH · grant
The wild-type p53-induced phosphatase Wip1 (PP2Cdelta or PPM1D) is a member of the serine/threonine protein phosphatase 2C (PP2C) family. Although Wip1 is expressed at low levels in most normal cells, its transcription is induced by p53 aft…
Posted May 21, 2026
Small Molecular Inactivators of HIV
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
We have developed and studied our molecule both in the active form and as a prodrug. We have developed large-scale syntheses for these molecules and worked in collaboration to study their antiviral activity and evaluate their preclinical to…
Posted May 21, 2026
Chemically Modified Peptide Nucleic Acids
US · IL NIH · grant
Our research on Peptide Nucleic Acids (abbreviated as PNAs) focuses on introducing chemical modifications that will make this class of molecules broadly useful to detect sequences of nucleic acids and also to inspire new types of small mole…
Posted May 21, 2026
Stress, race, and cognitive mediators of SES-related disparities in behavioral obesity treatment outcomes
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY/ABSTRACT Individuals of lower socioeconomic status (SES) lose only half as much weight in behavioral weight loss interventions as those of higher SES. This is a clinically meaningful difference in outcomes that has been cons…
Posted May 21, 2026
Hematologic Malignancies
US · IL National Cancer Institute (NCI) · grant
PROJECT SUMMARY Blood cancers afflict children and adults and are life-threatening. The Hematologic Malignancies (HM) Program is dedicated to understanding the causes of blood cancers and developing successful gene, drug, and cellular treat…
Posted May 21, 2026
Limited Competition for the Continuation of the Chronic Renal Insufficiency Cohort (CRIC) Hopkins Clinical Center
US · MD NIH (National Institutes of Health) · grant
PROJECT SUMMARY This application is submitted in response to RFA-DK-22-502, “Limited Competition for the Continuation of the Chronic Renal Insufficiency Cohort (CRIC) Clinical Centers (U01),” aka Phase 5 of CRIC, for the Hopkins/University …
Posted May 21, 2026
Mechanisms of Developmental Myelination
US · IL NIH · grant
PROJECT SUMMARY The long-term goal of this research program is to understand how specific axons of the developing central nervous system (CNS) are ensheathed with specific amounts of myelin, a specialized, proteolipid-rich membrane produced…
Posted May 21, 2026
A synaptogenic adhesion code for myelin specificity
US · IL NIH · grant
PROJECT SUMMARY Human brain function requires that neuronal axons are ensheathed by myelin, a specialized, lipid-rich membrane produced by oligodendrocytes, one of the principal glial cell types of the central nervous system. Myelin, the wh…
Posted May 21, 2026
Interrogating Mechanisms of Suppressed Tpex Immunotherapy Response in Metastatic Tumor-Draining Lymph Nodes
US · CA · San Francisco NIH · grant
PROJECT SUMMARY/ABSTRACT Tumor-reactive CD8 T cells become exhausted and lose their capacity to kill cancer cells in the tumor microenvironment. Progenitor-exhausted CD8 T cells (Tpex) found primarily in tumor-draining lymph nodes retain th…
Posted May 21, 2026
Characterizing stem cell-like B cell subpopulations and dissecting their role in tumorigenesis
US National Cancer Institute · grant
One third of B-cell lymphoma patients relapse and remain incurable despite effective targeted therapies. Although, the serially relapsing nature of these tumors support the presence of stem- like lymphoma repopulating cells, this notion rem…
Posted May 21, 2026
Identifying and Targeting 3D Regulatory Nodes that Maintain Glioblastoma Programs
US · IL NIH · grant
PROJECT SUMMARY Glioblastoma (GBM) is a highly aggressive and incurable brain tumor. The inter-patient and intra-tumoral heterogeneity of GBM, resulting from genetic alterations and epigenetic plasticity, poses a major challenge in its trea…
Posted May 21, 2026
Single-cell dissection of CD4 T cell changes in patients with immune-related adverse events following PD-1 inhibition
US National Institute of Arthritis and Musculoskeletal and Skin Diseases · grant
Project Summary This application proposes a five-year research and training plan with a scientific focus on the mechanisms through which PD-1 checkpoint inhibition leads to immune-related adverse events (irAEs). The hypothesis is that de no…
Posted May 21, 2026
Midbrain Signals for Differential Reinforcement Learning
US National Institute of Mental Health · grant
Project Summary/Abstract Associative learning is a fundamental cornerstone of behavior and cognition, but the underlying neural mechanisms remain poorly understood. In vertebrates, the inferior colliculus (IC) is a layered, midbrain hub imp…
Posted May 21, 2026
Learning Related Plasticity in Mammalian Sound Localization Circuits
US · IL NIH · grant
Project Summary / Abstract Binaural cues enable sound localization, which supports active listening by spatially segregating competing sound streams. Consequently monaural hearing loss impairs sound localization and listening comprehension,…
Posted May 21, 2026
Dendritic Mechanisms Underlying Behaviorally-Relevant Activity in a Descending Auditory Pathway
US · IL NIH · grant
Project Summary/Abstract Active listening is central to auditory cognition, supporting critical functions such as stream segregation, linguistic analysis and perceptual learning. To this end, the brain must accurately represent the physical…
Posted May 21, 2026
The Role of PICALM in Regulating Neurogenesis in Alzheimer's Disease
US · IL National Institutes of Health (NIH) · grant
Alzheimer’s disease (AD) is the most common cause of dementia worldwide. Ninety five percent of AD cases are sporadic late onset (LOAD) of unknown cause. Aging is the greatest risk factor of LOAD. Pathologically, AD is characterized by brai…
Posted May 21, 2026