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Showing 25 / 20086 · page 20/804
Hypothalamic neuronal circuits controlling survival behaviors
US National Institute on Drug Abuse · grant
Our interest is to understand how genetically identified cell types and their projections drive behaviors essential for survival. Using the mouse as our model system, we apply optogenetics and chemogenetics to manipulate neuronal circuits i…
Posted May 21, 2026
Regulation of the retinoblastoma (Rb) tumor suppressor by the ubiquitin-proteasome system
US · IL NIH · grant
PROJECT SUMMARY The retinoblastoma (Rb) protein is a prototypical tumor suppressor due to its role in restricting proliferation. In its active form, Rb functions as the key regulator of the G1/S cell cycle transition by physically binding t…
Posted May 21, 2026
Development of Strategies for the Enantioselective Synthesis of Heterocycles and Acyclic Amines
US National Institute of General Medical Sciences · grant
Project Summary/Abstract This objective of this proposal is to develop new synthetic methods for the enantioselective synthesis of bioactive molecules. Studies are centered on utilizing a new class of atropisomeric chiral biaryl ligand bein…
Posted May 21, 2026
Targeting the MET Pathway in Urothelial Carcinoma
US National Cancer Institute · grant
ICONIC-A phase 2 study of Ipilimumab, CabOzantinib, and NIvolumab in rare genitourinary (GU) cancers (ICONIC). This study includes 12 cohorts: bladder squamous cell carcinoma, bladder small cell carcinoma, bladder adenocarcinoma, bladder pl…
Posted May 21, 2026
Rare genitourinary tumors projects
US · IL NIH · grant
1. ICONIC-A phase 2 study of Ipilimumab, CabOzantinib, and NIvolumab in rare genitourinary (GU) cancers (ICONIC) The phase 1 study of combination CaboNivo and CaboNivoIpi included patients with rare GU histologies. Objective responses were …
Posted May 21, 2026
Bladder Cancer Program
US · IL NIH RePORTER · grant
I initiated a phase 3 clinical trial of adjuvant pembrolizumab post-cystectomy in patients with high-risk muscle-invasive urothelial carcinoma of the bladder and upper tract. I am the principal investigator on this Alliance/NCI-sponsored st…
Posted May 21, 2026
Using opioid industry documents to understand marketing of addictive medications
US National Institute on Drug Abuse · grant
ABSTRACT Prescription opioids have been a key driver of the US opioid crisis, resulting in nearly 500,000 overdose deaths from 1999 to 2019. The US has the highest rate of per capita opioid consumption in the world. Prior to class action la…
Posted May 21, 2026
Resource Development Core
US · IL NIH · grant
ABSTRACT: KIDNIT (Kidney Imaging: Developing Novel and Innovative Tools) is the Pittsburgh Center for Kidney Research’s Resource Development Core. Working in collaboration with kidney investigators and the Center’s Physiology and Model Syst…
Posted May 21, 2026
Role of AJC in umbrella cell function and dysfunction
US · IL NIH · grant
Abstract: A critical component of the umbrella cell barrier is the apical junctional complex (AJC), a multipartite, belt-like structure comprised of the tight junction, the adherens junction, desmosomes, and an associated cytoskeleton. Func…
Posted May 21, 2026
Mechanisms of cell death in cutaneous melanoma
US National Cancer Institute · grant
PROJECT SUMMARY The incidence of cutaneous melanoma is rising. While small molecule targeted inhibitors and immune checkpoint antibodies have increased long-term survival in advanced-stage cutaneous melanoma, many patients still do not bene…
Posted May 21, 2026
Development and validation of pain models in food animals
US · IL NIH · NAICS 541715 · grant
Development and validation of pain models in food animals Project Summary Each year, more than 65 million piglets, 1 million goats and 15 million calves in the U.S. undergo painful procedures such as tail docking, disbudding, and castratio…
Posted May 21, 2026
Predicting and Monitoring for Cardiac Toxicity in Pediatric AML
US · IL NIH · grant
Abstract: Children with acute myeloid leukemia (AML) receive the maximum cumulative anthracycline exposure during frontline therapy (>440 mg/m2), an exposure that causes very well-described cardiac complications. The importance of acute, s…
Posted May 21, 2026
Collaborative Pathways that Lead to Leukemia
US National Cancer Institute · grant
Mini-chromosome maintenance component 2 (Mcm2) is a DNA replication licensing factor that is part of the Mcm2-7 complex which functions as a DNA helicase, unwinding genomic DNA at the replication fork. Not surprisingly, homozygous deletion …
Posted May 21, 2026
Mutation Mechanisms Leading to Malignant Transformation, Including Chromosomal Translocation and Point Mutations
US · IL NIH · grant
It is well-established that many leukemias are initially sensitive to chemotherapy, but ultimately develop resistance. We have generated a panel of T-ALL cell lines, and have generated chemotherapy-resistatn derivatives of these cell lines,…
Posted May 21, 2026
Activation of Proto-Oncogenes by Chromosomal Translocation
US · IL NIH · grant
CENPA overexpression has been linked to several malignancies, and CENPA overexpression in yeast and cultured cell lines leads to chromosomal mis-segregation and subsequent aneuploidy. In collaboration with Dr. Munira Basrai of the Genetics …
Posted May 21, 2026
Pre-clinical Studies of Therapy for Myelodysplastic Syndrome
US · IL NIH · grant
We have modified a previously established in vivo model of myelodysplastic neoplasm (MDS) to now generate mice that have both wild type (WT) and NHD13 (MDS-derived) hematopoiesis by co-transplantation of WT and NHD13 hematopoietic stem cell…
Posted May 21, 2026
Genome-Wide CRISPR Activation: A Novel Strategy for Identifying Anti-Aging Targets
US National Institute on Aging · grant
The instrumental role of systematic gene knockdown studies, using RNA interference (RNAi), in identifying lifespan-extending gene alterations in model organisms like C. elegans is well established. In contrast, systematic gene overexpressio…
Posted May 21, 2026
Impact of metabolic programing of T cells from the GI tract and related tissues on HIV reservoir seeding, maintenance and reactivation
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
Two cases of virus eradication (the “Berlin patient” and the “London patient”) demonstrated that a cure for HIV infection is feasible. Meanwhile, the burden of the HIV epidemic, which spreads unabated, as such that for every person living w…
Posted May 21, 2026
Reducing Burnout among VA PCPs Using Evidence-Based Quality Improvement
US · IL Department of Veterans Affairs · NAICS 541720 · grant
Background: Burnout, a long-term psychological response to chronic workplace stress, is highly prevalent among providers and staff in VA primary care. Healthcare worker (HCW) burnout is not only detrimental to affected individuals, but also…
Posted May 21, 2026
Effects of Arginine Depletion Combined with Platinum-Taxane Chemotherapy in Aggressive Variant Prostate Cancers (AVPC)
US National Cancer Institute · grant
PROJECT SUMMARY/ABSTRACT Androgen indifferent prostate cancers account for a large proportion of the disease lethality and have limited therapy options, partly due to the lack of identifying biomarkers. To address the unmet need of develop…
Posted May 21, 2026
Deprescribing of Disease Modifying Agents in Older Adults with Multiple Sclerosis
US Agency for Healthcare Research and Quality · grant
PROJECT SUMMARY/ABSTRACT Disease Modifying Agents (DMAs) are vital for reducing inflammation and limiting disease activity in multiple sclerosis (MS). However, there is a decline in inflammation and disease activity in older adults with MS …
Posted May 21, 2026
Morphological and molecular identification of Hyalomma tick vectors of Crimean-Congo Hemorrhagic Fever virus
US · IL NIH · NAICS 541714 · grant
Project Summary/Abstract Ticks are obligate blood-feeders, temporary ectoparasites, and vectors of pathogens to humans and animals. Certain species of the genus Hyalomma are the principal vectors of the virus that causes Crimean-Congo hemor…
Posted May 21, 2026
The identification and interrogation of novel intracellular proteins that underlie the distinct nanoscopic architecture of Neurexin-1 and Neurexin-3
US · IL NIH · grant
Project Summary/Abstract Recent developments in super-resolution imaging have revealed that proteins involved in neurotransmitter release and detection are non-uniformly distributed and assemble into regions of high density called nanoclust…
Posted May 21, 2026
Biochemistry in situ to determine inheritance of RNA-protein complexes
US National Institute of General Medical Sciences · grant
Biochemistry in situ to determine inheritance of RNA-protein complexes The long-term goal is to elucidate the molecular mechanisms how macromolecular RNA-protein complexes transmit information to future generations of cells and progeny. We …
Posted May 21, 2026
Targeting purinergic signaling in Chagas disease
US National Institute of Allergy and Infectious Diseases · grant
Project Summary Chagas disease, a major public health problem in Latin America, is caused by the infection with the protozoan parasite Trypanosoma (T.) cruzi and has been spread to non-endemic regions by migratory movements. Chagas cardiomy…
Posted May 21, 2026