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20,086 contracts

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Showing 25 / 20086 · page 21/804
EEG Hyperscan to investigate the Patient-Clinician relationship following Theory of Mind Training
US National Center for Complementary and Integrative Health · grant
Project Summary/Abstract This R21 project aims to enhance therapeutic outcomes for Fibromyalgia (FM) patients by incorporating Theory of Mind (ToM) training into clinical practice. This training is designed to improve patients' ability to u…
Posted May 21, 2026
Initiating Colorectal Cancer Screening in Unscreened Individuals 45 to 54
US · IL NIH · grant
Colorectal cancer (CRC) is the first and second leading cause of cancer death in men and women under 50, respectively. Community health centers (CHCs) predominantly serve low-income individuals and have lower screening rates (41.9%) compare…
Posted May 21, 2026
Chip-Scale Intraoperative Optical Navigation with Immunotargeted Upconverting Nanoparticles
US · IL NIH · grant
Project Summary/Abstract Residual cancer cells left behind following surgery increase the chance of cancer returning in almost every cancer subtype. The current inability to identify these tumor cells during surgery hinders cancer care acr…
Posted May 21, 2026
Early identification of immunotherapy resistance through integrated multiparameter imaging
US National Cancer Institute · grant
PROJECT SUMMARY Immunotherapies for cancer have revolutionized oncology, but most patients do not experience durable responses. Immune checkpoint inhibitors targeting PD-1 and PD-L1 are now FDA-approved for a wide variety of tumors, but non…
Posted May 21, 2026
Developing a Single-Session, Peer-Delivered Internalized Stigma Reduction Intervention for Individuals with Polysubstance Use in Rural Maryland
US National Institute on Drug Abuse · grant
Project Summary/Abstract Rural communities bear a disproportionate burden of opioid and stimulant use, yet many individuals face challenges engaging in and sustaining treatment. Stigmas surrounding substance use disorder (SUD) and medicati…
Posted May 21, 2026
Erythrocyte-derived particles for near infrared phototherapy of port wine stains.
US · IL NIH · grant
Port wine stain (PWS) is a congenital and progressive malformations of the dermal capillaries. Pulsed dye laser (POL) irradiation in the visible wavelength range of 585-600 nm remains as the gold standard of treatment. The underlying tre…
Posted May 21, 2026
Microbiome-derived small molecules and host resistance against Vibrio cholerae
US National Institute of General Medical Sciences · grant
The human body is colonized by a complex microbial community with critical roles for health. This microbiota educates the immune system, helps digest our food, and protects us against pathogens. The diversity of microbes and encoded funct…
Posted May 21, 2026
Oseltamivir Use and Risk of Serious Neuropsychiatric Adverse Events in Children
US · IL National Institutes of Health (NIH) · grant
PROJECT SUMMARY/ABSTRACT Oseltamivir (Tamiflu) is the only Food and Drug Administration (FDA) approved influenza medication for children < 12 years. Yet, oseltamivir is under prescribed, including in children at high risk for influenza comp…
Posted May 21, 2026
Metabolic regulation of exosome biogenesis as a determinant of cancer cell metastasis.
US · IL NIH · grant
Abstract. The studies outlined in this proposal focus on the mechanisms by which aggressive breast cancer cells generate large numbers of exosomes with unique cargo, together with a total secretome that significantly enhances their potentia…
Posted May 21, 2026
Coordination of DNA Metabolism by Replication Protein A
US National Institute of General Medical Sciences · grant
Summary DNA metabolic processes including replication, repair, recombination, and telomere maintenance occur on single-stranded DNA (ssDNA). In each of these complex processes, dozens of proteins function together on the ssDNA template. How…
Posted May 21, 2026
Pre-synaptic events in homologous recombination and maintenance of genomic stability
US · IL NIH · grant
SUMMARY Lesions, breaks, and errors in DNA are drivers of genomic instability. Double-stranded DNA breaks (DSBs) are a particularly severe form of damage and are repaired by the homologous recombination (HR) pathway. On average, ~10 to 50 …
Posted May 21, 2026
Brain Health and Ethnic Disparities in ADRD Risk: The Case of Arab Americans
US · IL NIH · grant
Project Summary Brain Health and Ethnic Disparities in ADRD Risk: The Case of Arab Americans The incidence of Alzheimer’s disease and related dementia (ADRD) is higher in Black Americans and Hispanics than in non-Hispanic Whites, but data o…
Posted May 21, 2026
Investigating Transplacental Immune Pathways Contributing to Fetal Brain Pathology in Maternal Influenza
US · IL National Institutes of Health (NIH) · grant
Project Summary/Abstract The overarching goal of this application is to identify targetable transplacental immune signaling pathways for optimizing antenatal therapies that improve maternal and offspring health outcomes during seasonal infl…
Posted May 21, 2026
Targeting transcription and translation of the antisense CCCCGG repeat expansion in C9ORF72 ALS/FTD
US National Institute of Neurological Disorders and Stroke · grant
PROJECT SUMMARY Amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD) are devastating neurodegenerative diseases with no cure to date. The most common genetic cause of ALS/FTD is a hexanucleotide GGGGCC (G4C2) repeat exp…
Posted May 21, 2026
RFA-PS-21-004: Using Real-time Prescription Data to Support HIV Care and Treatment Adherence in NYC
US National Center for HIVAIDS, Viral Hepatitis, STD, and TB Prevention · grant
Project Summary CDC PS-21-004 This proposed project develops, implements, and evaluates a collaborative “Data-to- Care Rx” model using pharmaceutical insurance claims data to identify persons with HIV in real-time who fail to pick up prescr…
Posted May 21, 2026
Triage of Developmental and Reproductive Toxicants using an In vitro to In Vivo Extrapolation (IVIVE)-Toxicokinetic Computational modeling Application
US National Institute of Environmental Health Sciences · grant
1 PROJECT SUMMARY 2 3 A significant shift in the safety assessment of environmental chemicals is ongoing. This shift includes a reduction, 4 or in some cases elimination, of traditional toxicity testing in animals with the implementation…
Posted May 21, 2026
Immuno/Oncology (IO)
US National Cancer Institute · grant
The Immuno-Oncology Program (IO) established in 2021 unites basic, translational and clinical research scientists from the various disease site programs to address the urgent need to discover novel cancer immunobiologic processes that can b…
Posted May 21, 2026
Remotely-Delivered Cognitive Behavioral Stress Management Effects on Cancer-Accelerated Aging in Older, Distressed Breast Cancer Survivors
US · IL NIH RePORTER · grant
Protocol Synopsis-Brief Summary Study Overview. We will enroll Breast Cancer Survivors (BCS) who completed initial treatment within 3 – 12 months which may or may not have included chemotherapy, are continuing on adjuvant endocrine therapy …
Posted May 21, 2026
Core A: Biospecimen Repository and Pathology
US · IL NIH · NAICS 541714, 621511 · grant
CF1: Biospecimen Repository and Pathology Core ABSTRACT The Biospecimen Repository and Pathology Core (CF1) is designed to provide support to the basic and translational research efforts of the SPORE. CF1 will play a central role in collect…
Posted May 21, 2026
Defining the Role of Aminoacyl-tRNA Synthetases in Human Health and Disease
US · IL NIH · grant
PROJECT ABSTRACT Aminoacyl-tRNA synthetases (ARSs) are a ubiquitously expressed, essential class of enzymes responsible for ligating amino acids to cognate tRNA molecules. Importantly, all 37 loci encoding an ARS have been implicated in dom…
Posted May 21, 2026
All of Us Southern California Consortium (AoUSCC)
US NIH · grant
The overall goal of the All of Us Southern California Consortium, led by the University of California, Irvine, is to engage, recruit, and retain participants from the Southern California population with the goal to participate in the scient…
Posted May 21, 2026
Self-Powered In Vivo Joint Load and Angle Sensing in Total Knee Replacement
US National Institute of Arthritis and Musculoskeletal and Skin Diseases · grant
Project Summary Total knee arthroplasty (TKA) is one of the most common surgical procedures in all of medicine and despite technical advances, about 10-20% of patients remain dissatisfied with their outcomes and about 9% of patients require…
Posted May 21, 2026
Clinical Research Core
US · FL University of Florida (UF) Older Americans Independence Center (OAIC) · grant
The Clinical Research Core (RC1) is a key resource for the University of Florida (UF) Older Americans Independence Center (OAIC), providing the resources and expertise for conducting research across the spectrum of clinical investigation, i…
Posted May 21, 2026
Primary Cilia: A Novel Signaling Gateway To Neural Circuit Modulation
US · IL NIH · grant
PROJECT SUMMARY Primary cilium, a microtubule based antennae-like organelle, is present in every cortical neuron, and when defective, leads to ciliopathies. A distinguishing feature of ciliopathies is defective neural circuit formation and …
Posted May 21, 2026
DEFINING MECHANISMS OF PROGENITOR BALANCE AND NEURONAL CONNECTIVITY
US · IL NIH · grant
Principal Investigator (Last, First, Middle): Anton, Eva S. PROJECT SUMMARY Radial progenitors serve as an instructive matrix to coordinate the generation and placement of appropriate number and types of neurons in the developing cerebral c…
Posted May 21, 2026