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Showing 25 / 20086 · page 22/804
Deciphering the mechanisms mediating the dichotomous effects of fever on brain function and behavior
US · IL NIH · grant
The renewal of the animal protocol “Deciphering the mechanisms mediating the dichotomous effects of fever on brain function and behavior” was approved by the Animal Care and Use Committee on 07/29/2023. Despite the challenges posed by the l…
Posted May 21, 2026
K01 Menstrual Phase, Sexual Dysfunction, mTBI
US · IL National Institute of Neurological Disorders and Stroke (NINDS) · grant
Emerging research suggests that changes in sexual functioning after concussion/mild traumatic brain injury (mTBI) are common in women of reproductive age (18-45years). Findings from my pilot research show that 61.3% of women who sustain a c…
Posted May 21, 2026
The Retroelement LINE1 and the DNA Sensor IF16 in Sjogren's Syndrome
US National Institute of Arthritis and Musculoskeletal and Skin Diseases · grant
Project Summary/Abstract This award will promote the development of the applicant who seeks to acquire the skills and knowledge necessary to become an independent physician scientist focused on human rheumatic diseases. The research focus o…
Posted May 21, 2026
Elucidating the role of intestinal M cells in rotavirus enteric infection, systemic dissemination, and pathogenesis
US National Institute of Allergy and Infectious Diseases · grant
PROJECT SUMMARY/ABSTRACT Rotavirus (RV) is the leading cause of viral gastroenteritis in children under the age of 5 globally. Despite the introduction of several WHO-approved vaccines, RV infections still cause 114 million diarrhea episode…
Posted May 21, 2026
Great Plains Center for Agricultural Health
US · IL National Institutes of Health (NIH) · NAICS 541715 · grant
PROJECT SUMMARY/ABSTRACT – GREAT PLAINS CENTER FOR AGRICULTURAL HEALTH (OVERALL) The Great Plains Center for Agricultural Health conducts research and provides outreach to reduce the burden of injury and illness facing Midwest agricultural…
Posted May 21, 2026
Defining Protective IgGs to Food Allergy
US · IL National Institutes of Health (NIH) · NAICS 541714 · grant
Project Summary/Abstract Approximately 2% of the population of Western country is affected by peanut allergies. Peanut oral immunotherapy OIT has gained traction in the clinic as therapeutic option. However, successful peanut OIT resulting …
Posted May 21, 2026
Harnessing the anti-inflammatory activity of extracellular sialylation of IgG.
US · IL National Institutes of Health · NAICS 541714 · grant
Project Summary/Abstract. Despite the tremendous clinical success of immunotheraputics, little is known regarding IgG2-4 biology relative to IgG1. Our long-term goal is to understand how glycosylation of antibodies regulates, and is regulat…
Posted May 21, 2026
Non-Templated Regulation of IgE Mediated Anaphylaxis
US National Institute of Allergy and Infectious Diseases · grant
Project Summary/Abstract It is not clear why some individuals with allergen-specific IgE suffer from allergies, while others do not. It is likely that multiple factors contribute, including differences in IgE affinity or epitope diversity f…
Posted May 21, 2026
Delivery of a candidate AgTRIOVx malaria vaccine by thermostable microneedle patches
US · IL NIH · NAICS 541714 · grant
ABSTRACT Malaria remains one of the deadliest infectious diseases. Although much progress has been made in the fight against malaria, a highly effective and durable vaccine is not available. New vaccine candidates and improved delivery stra…
Posted May 21, 2026
Therapeutic vaccine platform to boost immune responses in Tuberculosis
US National Institute of Allergy and Infectious Diseases · grant
The goal of this SBIR Research Topic is to support small businesses in the development of new drug classes with novel mechanisms of action for HIV, Hepatitis B (HBV), and Tuberculosis (Mtb). HBV and Mtb drugs must be compatible with current…
Posted May 21, 2026
Scientific Conferences and Workshops for the American Psychopathological Association
US National Institute on Drug Abuse · grant
Each year, the Annual Scientific Conference and Workshop Program of the American Psychopathological Association is designed to provide bench science, clinical, and population health researchers with a high quality educational overview of sp…
Posted May 21, 2026
Role of NK cells in control of HCV infection associated hepatocellular carcinoma
US Veterans Affairs · grant
Remarkable advances with hepatitis C Virus (HCV) infection therapy have been made over the past 5 years,. At the same time, the peak of morbidity for the HCV epidemic, including outcomes such as cirrhosis and hepatocellular carcinoma (HCC) …
Posted May 21, 2026
Practice Facilitation to Enhance Implementation of a Pediatric Suicide Prevention Care Pathway
US · IL NIH RePORTER · grant
Project Summary Abstract Suicide is a leading cause of death in youth across the United States. Approximately 80% of youth who die by suicide interface with the medical system in the year preceding their death. Primary care practices (PCPs…
Posted May 21, 2026
Program for Advancing Early-Career Researcher Excellence through Leadership and Management Practices
US National Institute of General Medical Sciences · grant
Project Summary Background: Traditional scientific training prepares investigators to conduct scientific research, but does not adequately prepare early-career investigators to lead and manage their own labs. Yet, when early-career research…
Posted May 21, 2026
Immunoproteomic mechanisms of human macrophage resistance to Mycobacterium tuberculosis infection
US · IL NIH · grant
PROJECT SUMMARY / ABSTRACT Tuberculosis (TB) is the leading infectious killer worldwide. Upon exposure to Mycobacterium tuberculosis (Mtb), most people develop asymptomatic latent TB infection (LTBI phenotype). However, Dr. Anterasian's col…
Posted May 21, 2026
Deep sequencing of the HIV latent reservoir to discern mechanisms of clonal proliferation and HIV persistence
US · IL NIH · grant
PROJECT SUMMARY/ABSTRACT The HIV latent reservoir (LR) is the major barrier to cure of HIV. The persistence of the LR in blood and tissues in people living with HIV (PLWH) during ART is due to cellular proliferation of infected cells. Three…
Posted May 21, 2026
Machine learning and artificial intelligence research for clinical medical image processing
US National Library of Medicine · grant
ML/AI driven automated computer-aided diagnostic (CADx) tools are designed to detect, localize, classify and grade disease in medical images to augment human-expert decision-making, add efficiencies, and improve overall performance. However…
Posted May 21, 2026
Training Grant in Cancer Biology
US National Cancer Institute · grant
This revised application seeks renewal for Years 11-15 of the Training Program in Cancer Biology (T32CB) in the Greenebaum Comprehensive Cancer Center (UMGCCC) at the University of Maryland Baltimore (UMB). We are requesting support for 4 p…
Posted May 21, 2026
Proteolytic Pathways in Venous Thrombus Resolution
US Veterans Affairs · grant
Background / Rationale: VTE (Venous Thromboembolism) is a common and serious cardiovascular disease with significant mortality and morbidity. Prompt anticoagulation of patients with deep venous thrombosis (DVT) reduces fatal pulmonary embol…
Posted May 21, 2026
An engineered prodrug for inhibition of cancer growth and metastasis
US · IL NIH · grant
Treatments for metastatic and recurrent solid tumors, including ovarian, lung and colon cancers, remain a challenge due to lack of potent, selective and effective therapeutics. Clinically approved chemotherapies aim to slow or stop tumor gr…
Posted May 21, 2026
Chemotherapy induced MASP activation and ovarian cancer metastasis
US · IL NIH · grant
SUMMARY Metastasis is the leading cause of high mortality in epithelial ovarian cancer (OC) patients. The most common and insidious OC subtype, high-grade serous ovarian cancer (HGSOC), is often diagnosed after it has already metastasized b…
Posted May 21, 2026
Modulating the resolution of angiogenesis and normalization of the vasculature for therapeutic benefit
US · IL NIH · grant
Cardiovascular diseases are a leading cause of morbidity and mortality worldwide. Defective vascular repair or insufficient vascularization after disrupted or blocked blood flow often lead to ischemic peripheral artery diseases and other ca…
Posted May 21, 2026
2/2 PREEMPT: Prospective RandomizEd Evaluation and Management of Premature aTherosclerosis
US National Heart Lung and Blood Institute · grant
Abstract Failure to detect and treat atherosclerosis in younger adults worsens cardiovascular morbidity and mortality. Current strategies of assigning preventive therapies are not based on screening for atherosclerosis, but rather on short-…
Posted May 21, 2026
Developmental Origins of Aggressive and Impulsive Behavior
US · IL NIH · grant
Project Summary. Septal-hypothalamic neuronal activity centrally mediates aggressive behavior, while the monoamine neurotransmitters dopamine and serotonin play strong and mostly opposing modulatory roles. However, related circuit mechanism…
Posted May 21, 2026
Facilitating the Chemistry of Fluorosequencing
US · IL NIH · grant
ABSTRACT While advances in nucleic acid sequencing to achieve parallel and single molecule analysis have been astounding, analogous techniques for peptide/protein sequencing are lacking. Tandem mass-spec analysis still requires millions of …
Posted May 21, 2026