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Showing 25 / 20086 · page 23/804
Photoresponsive materials to study matricellular signaling dynamics during crypt formation and fission
US · IL NIH · grant
ABSTRACT The small intestine is lined with a single layer of epithelial cells that is organized into crypt-villus units. These epithelial cells perform multiple functions, such as aiding in digestion, nutrient absorbance, and serving as a b…
Posted May 21, 2026
Hydrogel matrices to study the role of inflammation and biological sex on aortic valve fibrocalcification
US National Heart Lung and Blood Institute · grant
ABSTRACT Thirteen percent of adults over 75 suffer from aortic valve stenosis (AVS), a progressive disease that leads to aberrant collagen deposition, leaflet stiffening, and eventual valve calcification at late stages. AVS is also sexually…
Posted May 21, 2026
Reversing age-related epigenetic changes and characterizing microglia heterogeneity in obesity and aging
US National Institute on Aging · grant
Project Summary Neuroinflammation is a hallmark of brain aging that may contribute to declines in function and neurodegenerative diseases. As the resident macrophage of the brain, microglial are crucial to brain maintenance but have been de…
Posted May 21, 2026
Stabilization of therapeutic microbes for inclusion in a liquid matrix for delivery to the intestines
US · IL NIH · grant
Project Summary/Abstract Enteral feeding (EF) is an essential medical procedure used to supply nutrients directly to the gastrointestinal (GI) tract of patients who are unable to eat independently. EF formula is often purchased as a ready-t…
Posted May 21, 2026
Platform technology for delivery of stabilized therapeutic microbes in powders with high water activity
US · IL NIH · grant
Project Summary/Abstract (NEC) in preterm infants affects 0.3-2.4 infants per 1,000 live births in the US and is a leading cause of mortality (mortality rate of up to 45%) and morbidity in premature babies. Although the pathogenesis of the …
Posted May 21, 2026
Neurobehavioral Effects of Frequent Co-use of Alcohol and Cannabis
US · IL NIH · grant
Project Summary Simultaneous use of alcohol and marijuana/cannabis (SAM) leads to increased craving, use, and consequences compared to single use of either alcohol or cannabis. However, there is a dearth of knowledge regarding the neural, n…
Posted May 21, 2026
MicroRNA directed pathway discovery in allergy and asthma
US · IL National Institutes of Health (NIH) · grant
PROJECT SUMMARY Asthma is a highly prevalent chronic inflammatory airway disease that is genetically and mechanistically linked to allergy and dysregulated cytokine-mediated communication between the airway epithelial barrier and tissue-in…
Posted May 21, 2026
Optimizing the Care of Acute Heart and Lung Diseases through Precision Triage and Inpatient Bed Assignment (OPTIBED)
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY Up to 16% of patients hospitalized with acute heart and lung diseases will die during their hospitalization. Mortality is up to three times higher when patients who need ICU-level care are initially triaged to a general care…
Posted May 21, 2026
Prediction of Heart Failure Onset using Multimodal Data Analysis, Deep Learning and Commercial Wearables
US National Heart Lung and Blood Institute · grant
Prediction of Heart Failure Onset using Multimodal Data Analysis, Deep Learning and Commercial Wearables Project Summary/Abstract Research: Heart failure is one of the leading causes of mortality and drivers of healthcare costs in the Unite…
Posted May 21, 2026
mitochondrial DNA leakage promotes inflammation and intervertebral disc degeneration
US · IL NIH · grant
Intervertebral disc (IVD) degeneration (IDD) is a major cause of low back pain, affecting 39% of American adults over the age of 18 and costing $87.6 billion in estimated healthcare expenditure. IDD is characterized by structural and functi…
Posted May 21, 2026
Oxytocin-mediated calcium signaling in physiologic uterine contractility and uterine atony
US Eunice Kennedy Shriver National Institute of Child Health and Human Development · grant
Project summary Postpartum hemorrhage (PPH) is the leading global cause of maternal morbidity and mortality. Uterine atony, insufficient uterine contractility after placental delivery, causes 80% of PPH. Oxytocin is the medical standard of …
Posted May 21, 2026
A new paradigm of general transcription factor TFIIB functionality in termination and promoter directionality
US National Institute of General Medical Sciences · grant
Project Summary Regulated transcription of genes is essential for cell proliferation, differentiation and viability. Any misregulation may lead to a disease or a developmental abnormality. The transcription cycle of eukaryotic genes consist…
Posted May 21, 2026
The Role of Dendritic Cells in Regulating the Gut-Brain Immune Axis in Ischemic Stroke
US · IL NIH · grant
Project Summary/Abstract Stroke is a prevalent and devastating disease with limited therapeutic options. Inflammation and immune cells are major components in the pathophysiology of ischemic stroke and contribute to acute and delayed tissue…
Posted May 21, 2026
Immune Privilege, CNS Autoimmunity, and Clostridium perfringens Epsilon Toxin
US · IL National Institutes of Health · grant
Why some people develop Multiple Sclerosis and others do not, despite similar genetic risk and quantities of circulating autoreactive lymphocytes, is not known. Our long-term goal is to identify environmental triggers of MS, define the mole…
Posted May 21, 2026
Impact of developmental serotonin on prefrontal cortex parvalbumin interneuron excitability and cognitive behavior
US · IL NIH · grant
PROJECT SUMMARY/ABSTRACT Sensitive periods are periods during early windows of development in external experiences or exposures can shape patterns of connectivity and behavior later in life. Such periods allow for circuit maturation to ada…
Posted May 21, 2026
ROC StARR: Health and Immune Function Across the Lifespan
US · NY · Rochester NIH · grant
Physician-scientists bring a unique perspective to biomedical research, informing clinically inspired basic science questions (bedside-to-bench), translating fundamental research back to the clinic (bench-to-bedside), and guiding implementa…
Posted May 21, 2026
AIM-for-RA
US · IL NIH · grant
Rheumatoid arthritis (RA) affects approximately 1% of the population and is characterized by inflammation and joint damage, often leading to considerable disability and pain in both early and established stages. Key areas of unmet need in t…
Posted May 21, 2026
Role of T-bet B cells in rheumatoid arthritis
US · IL NIH · grant
Although new treatments have improved outcomes in rheumatoid arthritis (RA), disability remains high, most patients have ongoing disease activity, and lasting remissions are rare. A major gap in the field is the elusive identity of pathogen…
Posted May 21, 2026
Adipose FHL1 in energy homeostasis
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
SUMMARY Tremendous advances have been made in the study of adipose biology but there are gaps in our understanding of adipose development and functions. The long-term goal of our research is to understand how adipose tissues regulate whole-…
Posted May 21, 2026
Neurobehavioral consequences of Mild Traumatic Brain Injury and addiction risk: a cotwin-control study
US National Institute on Drug Abuse · grant
Project Summary/Abstract The overall goal of the proposed study is to identify long-term neurobehavioral consequences of childhood mild traumatic brain injury (mTBI) for the developing brain and examine their contribution to addiction risk …
Posted May 21, 2026
Developing A Platform Technology For β-Cell-Targeted Drug Delivery
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
PROJECT SUMMARY Type 1 diabetes is characterized by the loss of β-cell mass and decreased insulin production capacity. Thus, developing a pharmacologic method for stimulating the expansion of β-cell mass has substantial potential therapeuti…
Posted May 21, 2026
Diabetes, Endocrinology and Metabolism Training Grant
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
Project Summary The T32 Training Program in Diabetes, Endocrinology and Metabolism at Stanford University (Endocrine T32) serves a national need to train physician and basic scientists in the fields of diabetes, endocrinology and metabolism…
Posted May 21, 2026
Operationalizing wastewater-based surveillance of multidrug-resistant bacteria
US · IL NIH RePORTER · grant
Multidrug-resistant organisms (MDRO) pose a significant risk to public health. Infections with MDRO are associated with high mortality rates and healthcare costs, particularly related to hospital-acquired pneumonia. Current approaches to co…
Posted May 21, 2026
Decoding multidrug-resistant pathogen dynamics for clinically-relevant wastewater surveillance
US · IL NIH · NAICS 541714 · grant
Multidrug-resistant bacteria (MDRB) contribute increasingly to morbidity, mortality, and healthcare costs. Extended-spectrum beta-lactam- and carbapenem-resistant Enterobacterales (ESBL-E and CRE) are MDRB of particular concern due to their…
Posted May 21, 2026
SARS-CoV-2 initiation and acceleration of AD pathology in the setting of endogenous and exogenous risk factors
US National Institute of Neurological Disorders and Stroke · grant
The uncertain etiology of Alzheimer’s disease poses significant obstacles to the development of both therapeutic and prevention strategies. At the root of this quandary is the fact that familial disease accounts for a very small fraction of…
Posted May 21, 2026