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20,086 contracts

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Showing 25 / 20086 · page 24/804
Genome-wide approaches to non-invasive screening and characterization of ovarian cancers
US National Cancer Institute · grant
PROJECT SUMMARY Ovarian cancer is the deadliest gynecological cancer, in part because there is no widely used screening test and 80% of tumors are diagnosed at a late stage. Though ovarian cancer screening has the poten>al to diagnose tumor…
Posted May 21, 2026
Engineering biomimetic 3D printed urethral tissue constructs using elastin-based bioinks for urethroplasty
US · IL NIH · grant
Project Summary Urethral defects requiring urethroplasty occur in children and adults secondary to congenital, traumatic, infectious, and malignant conditions. Current tissue sources for urethral replacement are limited by donor site morb…
Posted May 21, 2026
Engineering Tunable Biomimetic Adhesive Hydrogel to Deliver and Enhance MSC Function for Corneal Regeneration
US National Eye Institute · grant
Project Summary Corneal diseases pose a significant public health challenge in the United States, often leading to vision impairment and decreased quality of life. Mesenchymal stem cell (MSC) delivery to the cornea after a severe injury has…
Posted May 21, 2026
Cancer Aging and Metabolism research experience Program (CAMP)
US National Cancer Institute · grant
SUMMARY The Beckman Research Institute of City of Hope (COH) is a world-class cancer research institution and cancer hospital with a mission of turning science into practical benefit through exquisite care, innovative research, and vital ed…
Posted May 21, 2026
Core 1: Planning and Evaluation
US National Cancer Institute · grant
The goals of the Planning and Evaluation Core (PEC) are to monitor, evaluate, and assess the progress of our U54 Partnership in meeting its milestones, objectives, and goals. The PEC supports our University of California, Riverside (UCR)–Ci…
Posted May 21, 2026
Cancer Metabolism Training Program
US National Cancer Institute · grant
PROJECT SUMMARY Links between cancer and metabolic dysfunction were first discovered almost a century ago. Evidence acquired since indicates significant challenges remain in fully delineating those links and exploiting metabolism in the dia…
Posted May 21, 2026
Mechanisms that establish a functional stem cell niche during organogenesis
US National Institute of General Medical Sciences · grant
Project Summary/Abstract: Stem cells are required for tissue homeostasis and regeneration. Accomplishing these tasks requires intimate association with a niche, a cellular microenvironment that forms in a specialized tissue location with pr…
Posted May 21, 2026
Population Data Use and Management Core
US National Institute on Aging · grant
Project Summary/Abstract: POPULATION DATA USE AND MANAGEMENT RESOURCE CORE The Mount Sinai Older American Independence Center (MS-OAIC) aims to improve the independence and quality of life for older adults with serious illness, with a foc…
Posted May 21, 2026
Research Experience and Training Coordination Core
US National Institute of Environmental Health Sciences · grant
SUMMARY/ABSTRACT: Research Experience and Training Coordination Core The Superfund Research Program at the University of Iowa (ISRP) supports investigations of the consequences of sources and exposures to all airborne polychlorinated biphe…
Posted May 21, 2026
Investigating the contribution of a novel monocyte transcriptional state to sepsis immunopathogenesis and patient heterogeneity
US · IL NIH · grant
Project Summary/Abstract Sepsis is characterized by life-threatening organ failure caused by dysfunctional immune responses to infection; however, the specifics of immune dysfunction are poorly understood and vary widely among patients. Si…
Posted May 21, 2026
Fusion of nanomagnetic and viral tools to interrogate brain-body circuits
US National Center for Complementary and Integrative Health · grant
Abstract The information flow between the peripheral organs and the brain is increasingly recognized as bidirectional, with activity in peripheral circuits influencing high-level behaviors including mood, motivation, and stress. To establis…
Posted May 21, 2026
Development and Validation of an Implementation Penetration Assessment Criteria Tool (ImPACT-HPV) for HPV Vaccination in Nigeria
US National Cancer Institute · grant
There exists a research-to-practice gap that hinders the penetration of human papillomavirus (HPV) vaccination among adolescent girls and young women in Nigeria. To close this gap requires reliable, validated, easy-to-use tools to identify …
Posted May 21, 2026
Point-of-Care and Pharmacy-based Antiretroviral Drug Adherence Assays
US National Institute on Drug Abuse · grant
The Contractor, Guild Associates, Inc., aims to develop an electrochemical aptamer-based sensor device for simple, rapid, and low-cost detection and quantification of antiretroviral therapy (ART) drugs in urine and blood samples at the poin…
Posted May 21, 2026
Identification of genes involved in photoreceptor recognition and synapse formation
US · IL NIH (National Eye Institute - NEI's Retinal Disease Program) · grant
PROJECT SUMMARY/ABSTRACT Vision loss caused by the death of photoreceptors is a leading cause of irreversible blindness worldwide, yet therapeutic options remain limited. For this reason, the NEI's Retinal Disease Program has identified the…
Posted May 21, 2026
Role for nuclear matrix proteins and DNA methylation for XCI maintenance in female lymphocytes
US · IL NIH · grant
Females are predisposed for developing systemic lupus erythematosus (SLE), but the underlying mechanisms remain obscure. Females have two X-chromosomes and equilibration of X-linked gene dosage to that of males (XY) occurs by X-Chromosome I…
Posted May 21, 2026
Gene regulation mechanisms involving the inactive X in B cells during lupus disease
US National Institute of Allergy and Infectious Diseases · grant
Females are predisposed for developing systemic lupus erythematosus (SLE), but the underlying mechanisms remain obscure. Chronic inflammation is also a feature of SLE, and the majority of SLE patients have elevated type I interferon (IFN) l…
Posted May 21, 2026
Mechanisms linking dietary fiber, the microbiome, and satiety
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY/ABSTRACT This project supports the career development of Dr. Katherene Anguah in her path to become an independent translational researcher focusing on how dietary components may benefit cardiometabolic health through the co…
Posted May 21, 2026
Humanized Mouse Model of Gulf War Veterans' Illness
US Veterans Affairs · grant
Gulf War Veterans' Illnesses (GWVI) is a complex constellation of symptoms that have persisted in Gulf War Veterans (GWV) more than 25 years after their deployment to the Gulf. These symptoms are so diverse, they baffle diagnostic criteria.…
Posted May 21, 2026
Building Research Infrastructure for Alzheimer’s disease and Related Dementias in Côte d’Ivoire to Advance Global and U.S. Health Insights
US National Institute on Aging · grant
PROJECT SUMMARY Most research on Alzheimer’s Disease and Alzheimer’s-Related Dementias (AD/ADRD) is set in higher income contexts in North America, Europe, and Asia, yet (1) the burden of AD/ADRD is rapidly increasing in low- and middle-inc…
Posted May 21, 2026
Building Research Infrastructure for Alzheimer's Disease and Related Dementias in Cote d'Ivoire
US National Institute on Aging · grant
PROJECT SUMMARY Most research on Alzheimer’s Disease and Alzheimer’s-Related Dementias (AD/ADRD) is set in higher income contexts in North America, Europe, and Asia, yet (1) the burden of AD/ADRD is rapidly increasing in low- and middle-inc…
Posted May 21, 2026
Treatment and prevention of osteoarthritis with an intra-articular disease-modifying regenerative therapy
US · IL NIH-NIAMS · NAICS 325412 · small business · grant
Abstract Osteoarthritis (OA), a degenerative joint disorder, affects nearly 10% of the US population. Costs—including loss of work, medications, hospitalization for joint replacement and/or repair surgery, and other types of therapy—are hig…
Posted May 21, 2026
Transposon control as a checkpoint during regeneration
US · IL NIH · grant
PROJECT SUMMARY / ABSTRACT Tissue regeneration is the process through which damaged tissue is restored to its original structure and function. There is wide variation across species in their regenerative ability. For example, zebrafish can…
Posted May 21, 2026
Using Glycomic Signatures to Monitor Disease Progression and Predict Treatment Response in Lupus Nephritis
US · IL NIH · NAICS 541714 · grant
Abstract Systemic lupus erythematosus (SLE) is one of the most common autoimmune disorders, predominantly affecting women of childbearing age. Up to half of all lupus patients develop lupus nephritis (LN), a severe kidney disease characteri…
Posted May 21, 2026
Pilot Testing Implementation of Suicide Risk Prediction Algorithms to Support Suicide Prevention in Primary Care
US National Institute of Mental Health · grant
PROJECT SUMMARY In 2020, suicide was among the top three causes of death for adolescents and young adults (age 10-34) and among the top nine for adults (age 35-64). Recently, researchers have successfully developed suicide risk prediction a…
Posted May 21, 2026
The TRANS-SAFE Patient Safety Learning Lab: Systems Improvement for Psychosocial Safety in Transgender Care
US · IL Agency for Healthcare Research and Quality (AHRQ) · grant
This patient safety learning laboratory (PSLL) will address the intersection of two major gaps in the science of patient safety: 1) psychosocial patient harm / avoidable patient suffering, and 2) patient safety for transgender individuals. …
Posted May 21, 2026