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20,086 contracts

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Showing 25 / 20086 · page 25/804
RFA-DP-24-031: Longitudinal Follow-up of a Nationwide Multiethnic Cohort of Veterans and Non-Veterans with Interstitial Cystitis
US · IL NIH RePORTER · grant
ABSTRACT Interstitial cystitis/bladder pain syndrome (IC) is characterized by pain related to the bladder, usually with frequency and urgency, in the absence of other diseases that could cause these symptoms. Given the difficulty in diagnos…
Posted May 21, 2026
Anatomical and functional organization of inter-areal feedback circuits in the visual cortex, and their impact on neuronal responses
US National Eye Institute · grant
In the mammalian sensory cortex, hierarchically-organized areas are reciprocally connected via feedforward (FF) and feedback (FB) circuits. FF connections generate the more complex response properties of neurons in higher areas within paral…
Posted May 21, 2026
Connectivity and function of inhibitory neurons in the primate visual cortex
US · IL NIH · NAICS 541715 · grant
PROJECT SUMMARY In the mammalian neocortex, cortical computations result from the activity of neural circuits composed mainly of glutamatergic excitatory and GABAergic inhibitory neurons (INs). INs profoundly influence cortical computations…
Posted May 21, 2026
Medical Student Research Program (MSRP) in Eye Health and Disease
US · UT National Eye Institute (NEI) / NIH · grant
To meet the healthcare challenges on which the NEI focuses, it is essential that we nurture and build the physician-scientist workforce, preparing medical students from all areas of the US to become tomorrow’s researchers. Over the past thr…
Posted May 21, 2026
Project 2: Cellular topography and function of the breast cancer tissue microenvironment
US · IL NIH · grant
Abstract/Project Summary Breast cancer (BC) metastasis is an emergent feature that occurs when the tumor’s ability to recruit metabolic resources, avoid immune activation, and disseminate to distant sites exceeds the capacity of surrounding…
Posted May 21, 2026
Machine Learning Prediction of Persistent Adverse Mental Health Outcomes for Autistic Children: Leveraging Social Determinants of Health from Clinical Data
US · IL NIH · grant
PROJECT SUMMARY/ABSTRACT Autistic children and youth have high utilization of emergency department visits and inpatient stays for psychiatric indication. There is a need to understand who is at the greatest risk for adverse mental health ou…
Posted May 21, 2026
Characterizing gastrointestinal disorder trajectories for autistic sub-groups: Machine learning prediction of risk profiles and response to treatment
US · IL NIH · grant
PROJECT SUMMARY/ABSTRACT Gastrointestinal (GI) problems are one of the most common concerns reported by families of autistic children and youth and can have significant lifelong impacts on health, quality of life, and participation. Existin…
Posted May 21, 2026
Immunometabolic signatures of BCG-induced neonatal trained immunity
US · MA · Boston NIH · grant
Project Summary/Abstract This proposal presents a 5-year research career development program focused on the study of Bacille Calmette- Guérin (BCG) vaccine and the mechanisms of innate immune memory, otherwise known as trained immunity, und…
Posted May 21, 2026
Optimizing methotrexate use for the management of chronic pediatric non-infectious uveitis
US · IL National Institutes of Health (NIH) · NAICS 541714 · grant
PROJECT SUMMARY Pediatric chronic non-infectious uveitis (NIU) is an inflammatory ocular disease that has a substantial risk for sight-threatening complications. Methotrexate (MTX) is the preferred first line systemic treatment for all subt…
Posted May 21, 2026
Genetically engineered mouse models to investigate the liposarcoma microenvironment
US · IL NIH · grant
PROJECT SUMMARY/ABSTRACT Liposarcoma (LPS) is the most common type of soft tissue sarcoma. The most common subtypes are well- differentiated (WDLPS) and dedifferentiated (DDLPS) liposarcoma which are characterized by genomic amplification o…
Posted May 21, 2026
Durability of memory T cell responses in melanoma
US · IL NIH · grant
PROJECT SUMMARY/ABSTRACT Melanoma is the most lethal type of skin cancer. About 50% of patients with metastatic melanoma have a meaningful response to treatment with immunotherapy, of which some develop a durable response. Many patients wit…
Posted May 21, 2026
Core Vision Grant - Design & Fabrication
US National Eye Institute · grant
Abstract The Design and Fabrication Module supports vision research at New York University by providing an expert in CAD/CAM design and fabrication to assist vision researchers in designing custom equipment and managing fabrication at at NY…
Posted May 21, 2026
Neural Mechanisms of Vestibular Function
US · IL NIH · grant
PROJECT SUMMARY We investigate an important function of the vestibular system, and its multisensory properties, in spatial navigation, specifically head direction (HD) cells. HD cells encode directional heading like a compass and these prop…
Posted May 21, 2026
The role of an unusual variant nucleosome in Toxoplasma gondii life cycle
US National Institute of Allergy and Infectious Diseases · grant
Program Director/Principal Investigator (Last, First, Middle): Sergio Oscar Angel ABSTRACT The parasite Toxoplasma gondii has infected up to one-third of the world’s population and can cause spontaneous abortion, birth defects, neurologic …
Posted May 21, 2026
Conference Series on Aging in the Americas: United States and Mexico-Renewal
US · IL National Institutes of Health (NIH) · grant
Project Summary  Hispanic populations in the United States and Latin America will confront critical health issues in the 21st century. In the United States, poverty among older Hispanic individuals is twice as high as that for non-Hispanic …
Posted May 21, 2026
Assessing central muscarinic acetylcholine type-1 receptors in cocaine use disorder with 11C-LSN3172176.
US · IL National Institute on Drug Abuse (NIDA) · grant
PROJECT SUMMARY/ABSTRACT The recent resurgence in cocaine use in the U.S. is a significant public health concern and there is an urgent need to address the long-standing absence of effective treatments for cocaine-use disorder (CUD). Highl…
Posted May 21, 2026
Imaging Brain Kappa Opioid Receptors in Early Abstinence Opioid Use Disorder
US · IL National Institute of Health · grant
Abstract Imaging Brain Kappa Opioid Receptors in Early Abstinence Opioid Use Disorder The opioid epidemic is one of the worse U.S. public health crises of the past three decades [1]. In response to this epidemic, the National Institute of H…
Posted May 21, 2026
Aberrant Synaptic Plasticity in Cocaine Use Disorder: A 11C UCB J PET Study
US · IL NIH · grant
Abstract In seminal preclinical studies nearly 20 years ago, Robinson & Kolb [1, 2] demonstrated enduring changes in synaptic (dendritic spine) density in medial prefrontal cortex (mPFC) of rodents following behaviorally sensitizing regimen…
Posted May 21, 2026
South Dakota Pediatric Clinical Trials Network (SoDakPCTN)
US National Institutes of Health (NIH) · grant
PROJECT SUMMARY This proposal seeks to con�nue to build pediatric clinical trials capacity in South Dakota through the South Dakota Pediatric Clinical Trials Network. The Avera Health system and partners are ideally suited to conduct pediat…
Posted May 21, 2026
Training Component
US · IL NIH · grant
PROJECT SUMMARY The overall goal of the MARCH Training Component is to enhance knowledge and skills for investigators and community partners to conduct research and improve care for pregnant women to reduce the risk of pregnancy-associated …
Posted May 21, 2026
A 3D zebrafish microanatomical and gene expression atlas for disease modeling
US NIH Office of the Director · grant
Project Summary The zebrafish is a vertebrate model organism with significant genetic, cellular, and physiological similarities with humans. Its powerful genetic and imaging tools have allowed us to decipher gene function, embryonic develop…
Posted May 21, 2026
Ultrafast Biophysical Studies of Biomolecules at the NIH
US · IL NIH · grant
In 2024, we introduced a major update of the software used by the Bax group to control our home-built Icarus-I and Icarus-II pressure jump systems. This release was coded by Sean Fitch, a computer science undergraduate who offered his servi…
Posted May 21, 2026
Ultrafast Biophysical Studies of Biomolecules at the APS
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
Our time-resolved x-ray studies of biomolecules have been pursued on the BioCARS beamline at the Advanced Photon Source (APS), which shut down operations in May 2023 to implement a major upgrade (APS-U) that aims to reduce significantly the…
Posted May 21, 2026
Evaluating Ghost Pipe (Monotropa uniflora) as a Potential Source of Novel Analgesic Compounds
US · IL NIH · grant
PROJECT SUMMARY/ABSTRACT Chronic pain is one of the most common reasons for seeking medical care, affecting 50 million Americans. While often treated with opioid pharmaceutical or surgical interventions, complementary traditional health app…
Posted May 21, 2026
Identifying patient subgroups and processes of care that cause outcome differences following ICU vs. ward triage among patients with acute respiratory failure and sepsis
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY Decisions to admit patients with acute respiratory failure (ARF) and sepsis (the most common and lethal cause of the acute respiratory distress syndrome) to intensive care units (ICUs) are highly variable across the US. And,…
Posted May 21, 2026