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Mapping dynamic functional networks across environments and backgrounds
US · IL NIH · NAICS 541714 · grant
Genome sequencing has provided an unprecedented view into the extent of human genetic variation. Yet, our ability to link specific genetic variants to phenotypes remains limited. Moreover, genetic interactions between complex combinations o…
Posted May 21, 2026
Allostatic load, stress Response to Social Stress, frequency of Stress Exposure, and social Network structure/function (ARSEN)
US National Institute on Minority Health and Health Disparities · grant
This project tests how various forms of social stress contribute to allostatic load and related health risk, and how aspects of social support networks may mitigate negative health effects of stress by reducing stress contagion. Our project…
Posted May 21, 2026
Innovative In-Situ Imaging Techniques for the Visualization of CNS associated HIV reservoirs in the Context of Substance Abuse
US · IL NIH · grant
Despite advances in our understanding of HIV pathogenesis, a knowledge gap remains concerning HIV viral reservoirs. Unknowns include, their various locations, size of the reservoir and the spatial/temporal kinetics for reservoir establishme…
Posted May 21, 2026
Synthetic fentanyls adversely affect the blood-brain barrier and HIV replication in the context of neuroHIV
US · IL NIH · NAICS 541714 · grant
In the past two to three decades, there has been a surge in the use, abuse, and misuse of opioids. Among opioid users, Illicit fentanyl use has become widespread in the US. Moreover, synthetic fentanyls rapidly flood the illicit drug market…
Posted May 21, 2026
29th-31st Scientific Conference Society on NeuroImmune Pharmacology
US National Institute on Drug Abuse · grant
The Society on Neuroimmune Pharmacology (SNIP) scientific meetings are focused on uncovering how substance abuse renders humans more susceptible to infection and chronic diseases, with a particular focus on human immunodeficiency virus-1 (H…
Posted May 21, 2026
GPCR signaling during embryonic organ formation
US · IL NIH · NAICS 541715 · grant
G-protein coupled receptors (GPCRs) are critical for almost every aspect of animal life. These proteins are embedded in the cell membrane and allow us to sense and respond to light, smells, and taste. GPCRs also control responses in both ou…
Posted May 21, 2026
Formation of the Drosophila salivary gland
US · IL NIH RePORTER · NAICS 541715 · grant
The FoxA family of winged-helix DNA-binding transcription factors (TFs) play major roles in the development of many organs in vertebrate embryos. In some cases, they are proposed to be determinants of specific cell fates because they are ex…
Posted May 21, 2026
Neuroinformatics Research Core
US · KS Kansas State University · grant
PROJECT SUMMARY: NEUROINFORMATICS CORE The Neuroinformatics (NI) Core was established at Kansas State University (K-State) with Phase 1 COBRE funding to support the primary projects, programs, and cores across CNAP. In Phase 2, the NI Core …
Posted May 21, 2026
The role of the RNA binding protein IMP1 in intercellular communication and necrotizing enterocolitis
US · IL National Institutes of Health (NIH) · grant
PROJECT SUMMARY Necrotizing enterocolitis (NEC) is a devastating inflammatory disease that affects the intestine of premature infants. There is major gap in our understanding of the pathophysiology of NEC, including no cure for this often d…
Posted May 21, 2026
Deciphering the Molecular Puzzle: IMP1 Modulation of Mucus Integrity in Necrotizing Enterocolitis
US · IL NIH · grant
SUMMARY Necrotizing enterocolitis (NEC) is a devastating inflammatory disease that affects the intestines of premature infants. There is a major gap in our understanding of the factors that contribute to the pathophysiology of NEC, includin…
Posted May 21, 2026
Caregiver Cry Perception and Developmental Trajectories of Infant-Caregiver Interactions Involving Cry as an Early Marker of Autism
US National Institute of Mental Health · grant
Project Summary Caregivers of children with autism spectrum disorders often recall differences in their children as early as infancy, despite most children with autism being diagnosed after age 3. Caregiver recall of behavioral differences …
Posted May 21, 2026
Perinatal PFAS Impact Children's Development: Examining the Roles of Placental Functional Multiomics and Protection by Maternal Exercise
US · IL NIH · grant
PROJECT SUMMARY The perinatal period is well-recognized as a critical developmental window where organ systems are rapidly growing and tuning their functional programs. This is also a time when environmental exposures can have profound and …
Posted May 21, 2026
Structural Studies of a T cell Specific Tyrosine Kinase
US · IL NIH · grant
Project Summary T cell development, activation, and differentiation are all dependent on TCR signaling, along with important contributions from costimulatory and cytokine receptor pathways. Many lines of evidence indicate that variations in…
Posted May 21, 2026
Understanding the Role and Regulation of Epithelial Ketogenesis in the Colon
US · IL NIH · grant
Abstract Intestinal stem cells (ISCs) play pivotal roles in intestinal epithelium renewal during homeostasis and after injury. The metabolic demands faced by ISCs require high mitochondrial oxidative phosphorylation (OXPHOS) activity compar…
Posted May 21, 2026
Investigating the Ferrostatic Role of Adipose Tissue Macrophages
US · MA National Institutes of Health · grant
PROJECT SUMMARY Iron is a micronutrient that is essential for nearly every living organism, and maintaining its homeostasis therefore represents a crucial biological problem across all scales: from cells, to tissues, to the whole organism.…
Posted May 21, 2026
The RAW Brain - The Effect of Rumination, Anxiety and Worry on Aging and Dementia Risk
US · IL NIH · grant
Anxiety and its disorders are a risk factor for several major diseases of aging including cardiovascular and auto- immune diseases, Alzheimer's Disease and related dementias (ADRD). As anxiety disorders have the highest lifetime prevalence …
Posted May 21, 2026
Ph1/2 Study of the Imipridone ONC201 for Treatment of AML IND125,203 (12/23/2014)
US Food and Drug Administration · grant
Project Summary/Abstract Survival rates (app. 30 %) of acute myeloid leukemia (AML) have not been improved over 4 decades, except in some specialized instances. The long term aim of this study is to increase the cure rates of AML through cl…
Posted May 21, 2026
Transcriptional regulation of mammary gland development
US · IL Eunice Kennedy Shriver National Institute of Child Health and Human Development · grant
Mammary gland development and function requires precise stage and spatial control of transcriptional programs. These processes are tightly controlled to ensure the successful function of the mammary gland, including lactation which is essen…
Posted May 21, 2026
Metabolic mechanisms of cognitive decline in aging and AD mediated by inflammatory PGE2 signaling
US · IL NIH · grant
Metabolic mechanisms of cognitive decline in aging and AD mediated by inflammatory PGE2 signaling Project Summary Aging is characterized by the development of maladaptive immune responses that promote cognitive decline and Alzheimer’s disea…
Posted May 21, 2026
The role of peripheral versus brain myeloid immunity in the cognitive decline of aging and Alzheimer's disease
US · IL NIH · grant
The role of peripheral versus brain myeloid immunity in cognitive decline of aging and Alzheimer’s disease Aging is characterized by the development of detrimental immune responses, where sustained pro-inflammatory responses promote end-org…
Posted May 21, 2026
Reprogramming myeloid cell metabolism to prevent cognitive aging and Alzheimer's Disease
US · IL NIH · grant
REPROGRAMMING MYELOID CELL METABOLISM TO PREVENT COGNITIVE AGING AND ALZHEIMER’S DISEASE SUMMARY The brain is highly vulnerable to aging, as demonstrated by the high prevalence of age-associated cognitive decline and Alzheimer’s disease (A…
Posted May 21, 2026
Influence of the Menopausal Transition and Lifetime Ovarian Exposure on Neural Metabolism, Connectivity and Pathology
US · IL NIH · grant
Women are significantly more likely to develop Alzheimer’s disease than men, making up 2/3 of all AD cases. Growing evidence suggests that this difference is related to the decline in ovarian hormone levels experienced by women at midlife t…
Posted May 21, 2026
L-Rha and L-Rha Derivatives and Their Effects on Neurodegenerative Alzheimer's Disease
US National Institute on Aging · grant
Project Summary A rare sugar, L-rhamnose (L-Rha) and L-Rha-containing molecules demonstrated unique effects on Alzheimer’s disease (AD). Despite its importance in human health, it is still not clear how L-Rha plays a role in activation of t…
Posted May 21, 2026
Investigation of the effects of interleukin-10 shear thinning hydrogel on human oligodendrocyte progenitor cell survival and differentiation following transplantation
US National Institute of Neurological Disorders and Stroke · grant
ABSTRACT Some of the most devastating neurodegenerative diseases such as multiple sclerosis, are characterized by chronic demyelination and a tissue environment that prevents efficient myelin repair and remyelination. While cell therapies h…
Posted May 21, 2026
Programmable Hydrogels for Optimized Human Oligodendrocyte Transplantation in Demyelinating Disease
US National Institute of Neurological Disorders and Stroke · grant
ABSTRACT Some of the most devastating neurodegenerative diseases such as multiple sclerosis, are characterized by chronic demyelination and a tissue environment that prevents efficient myelin repair and remyelination. While cell therapies h…
Posted May 21, 2026