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Showing 25 / 20086 · page 28/804
Evaluating a Multilevel Communication Campaign to Increase HIV Vaccine Trial Enrollment
US · IL National Institutes of Health (NIH) · NAICS 541715, 541810, 541820 · grant
Project Summary/Abstract The HIV Vaccine Trials Network (HVTN) has experienced significant challenges recruiting participants in early-stage HIV vaccine clinical trials. Formidable barriers to participation in HVTN preventive HIV early phas…
Posted May 21, 2026
Evaluating state policies to facilitate emergency department-based treatment initiation for opioid use disorder
US · IL NIH · NAICS 541720 · grant
Opioid use disorder (OUD) is a life-threatening health condition affecting 7.6 million people in the U.S. Medications for opioid use disorder (MOUD), such as methadone and buprenorphine, decrease mortality among patients with OUD by 50%. Em…
Posted May 21, 2026
Izumo1 in remission in SLE
US · IL NIH RePORTER · grant
PROJECT SUMMARY/ABSTRACT Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of variable severity and course. The disease is characterized by a tendency for flares, in which symptoms get worse, followed by periods of quiescen…
Posted May 21, 2026
The role of cytotoxic T cells in rheumatoid arthritis pathogenesis
US National Institute of Arthritis and Musculoskeletal and Skin Diseases · grant
PROJECT SUMMARY/ABSTRACT Significant data implicate a role for autoantibodies to citrullinated proteins in RA pathogenesis, and autoantibodies to the citrullinating enzyme peptidylarginine deiminase 4 (PAD4) are also found in a subset of pa…
Posted May 21, 2026
Insights into the origin of ACPAs in RA
US · IL NIH · grant
PROJECT SUMMARY/ABSTRACT Citrullination is a physiologic post-translational modification found across multiple normal human tissues. Why this modification is the most important target of antibodies in rheumatoid arthritis (RA) is unknown. W…
Posted May 21, 2026
The antigenic origin of anti-dsDNA antibodies in SLE
US National Institute of Allergy and Infectious Diseases · grant
PROJECT SUMMARY/ABSTRACT Anti-dsDNA antibodies are serological hallmarks of systemic lupus erythematosus (SLE), and key markers for diagnosis and disease activity. The close association of anti-dsDNA antibodies with SLE has suggested that u…
Posted May 21, 2026
CaV2.2 splice variants in the hippocampus: function and pharmacology
US National Institute of Mental Health · grant
The effects of cannabinoids are diverse and dose dependent. For instance, low doses produce anxiolysis whereas high doses induce anxiety; similar effects have been seen on memory and cognition. However, the reasons for this are not clear. A…
Posted May 21, 2026
SULT4a1, a novel neuroprotective protein in stroke
US · IL NIH · grant
Stroke remains a leading cause of death and morbidity in the USA and lacks effective therapeutic interventions. Redox imbalance and mitochondrial dysfunction are considered as leading causes of cell death in stroke. Identification of novel …
Posted May 21, 2026
B cell lineage directed rational vaccine strategies based on CAP256SU Env-Ab coevolution
US National Institute of Allergy and Infectious Diseases · grant
PROJECT SUMMARY/ABSTRACT: The development of an effective HIV vaccine remains a major challenge. Previous strategies for HIV vaccine design aimed to elicit protective T cell responses, non-neutralizing antibodies, broadly neutralizing antib…
Posted May 21, 2026
Project 1: Immunogen Design and Delivery
US National Institute of Allergy and Infectious Diseases · grant
PROJECT SUMMARY/ABSTRACT The development of an effective HIV vaccine remains a major challenge. Previous strategies for HIV vaccine design aimed to elicit protective T cell responses, non-neutralizing antibodies, broadly neutralizing antibo…
Posted May 21, 2026
Rationally designed targeted immunogens to elicit HIV Envelope V2-apex broadly neutralizing antibodies
US National Institute of Allergy and Infectious Diseases · grant
OVERALL: PROJECT SUMMARY Our primary goal in this IPCAVD program is to develop a germline-targeting priming immunogen for the HIV Envelope V2-apex broadly neutralizing antibody (bnAb) site. We aim to test its ability to activate V2-apex bnA…
Posted May 21, 2026
Development of pan-betacoronavirus vaccines
US · IL NIH · NAICS 541714 · grant
PROJECT SUMMARY/ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus identified at the end of 2019, has led to the current global pandemic. The SARS-CoV-2 virus belongs to the subgenus sarbecovirus of t…
Posted May 21, 2026
Combining germline-targeting, B cell immunofocusing and Env-Ab coevolution strategies to induce HIV Envelope V2-apex broadly neutralizing antibodies
US National Institute of Allergy and Infectious Diseases · grant
PROJECT SUMMARY/ABSTRACT: The development of an effective HIV vaccine has proven to be a daunting challenge. Previous strategies for HIV vaccine design aimed to elicit protective T cell responses, non-neutralizing antibodies, broadly neutra…
Posted May 21, 2026
Investigation and application of hydrocarbon-degrading enzymes using cryo-electron microscopy and directed evolution
US · IL National Institutes of Health (NIH) · grant
Glycyl radical enzymes (GREs) are a growing superfamily that catalyzes an impressive array of chemical transformations critical to human health. GREs share a common glycyl radical cofactor, which allows them to perform challenging, otherwis…
Posted May 21, 2026
Engineering radical enzymes for asymmetric olefin hydroalkylation
US National Institute of General Medical Sciences · grant
PROJECT SUMMARY: The synthesis of biologically active molecules through selective C–C bond-forming reactions is central to the discovery of new therapeutics. Though forging C–C bonds is often more challenging at C(sp3)-centers than C(sp2)-c…
Posted May 21, 2026
Simplifying the transformation of laboratory test data for integration into the ImmPort database
US · IL NIH/NIAID · grant
Project Summary/Abstract The sharing of data in biomedical research, including data generated from clinical trials, is paramount for ensuring reproducibility, improving study design, increasing analytic power via concatenation of disparate …
Posted May 21, 2026
Characterizing cytotoxic therapy induced shifts in the cost-to-benefit ratio of high ploidy
US National Cancer Institute · grant
SUMMARY Traditional phase I dose-finding strategies monitor drug response only for two weeks, based on the assumption that it will suffice to observe how therapy affects doubling time of a homogeneous population over 2-4 generations. But with …
Posted May 21, 2026
The Effect of Exercise on T Cell Aging in Rheumatoid Arthritis
US · IL NIH · grant
Abstract Exercise training is linked to beneficial effects on maladaptive immune aging. In patients with rheumatoid arthritis (RA), exercise training is a disease modulating therapy and may improve premature biological aging inherent in RA,…
Posted May 21, 2026
Protein Allostery and Catalysis Beyond Bragg Diffraction
US · IL NIH · grant
Abstract The central goal of this project is to understand how protein motion gives rise to function. However, visualizing proteins in motion is a problem that is inherently difficult in structural biology as it involves signals from many c…
Posted May 21, 2026
Deciphering the role of junctional adhesion molecule-A in neutrophil-driven inflammatory response in Alzheimer disease
US · IL NIH · grant
Accumulating evidence suggests that Alzheimer’s disease (AD)-related inflammation progresses in two different but interrelated compartments: the blood and the brain, implying that leukocytes could lead to “brain activation,” while brain inf…
Posted May 21, 2026
DP21-001 Utah Pregnancy Risk Assessment Monitoring System (PRAMS)
US · UT Utah Department of Health · grant
Since 1999, the Utah Department of Health (UDOH) has conducted the Pregnancy Risk Assessment Monitoring System (PRAMS) survey to help improve understanding of maternal behaviors and their relationship to pregnancy outcomes and to develop po…
Posted May 21, 2026
Mapping spatiotemporal dynamics during enterovirus infection across cells and tissues
US · IL NIH · grant
Project Summary Human enterovirus (HEV) infections primarily affect infant and adolescent populations, causing a wide range of clinical manifestations that commonly include respiratory illness and mucocutaneous lesions, or hand, foot and mo…
Posted May 21, 2026
Elucidating the structural adaptation of HIV-1 capsids during critical host-factor interactions
US · IL NIH · NAICS 541714 · grant
PROJECT SUMMARY The HIV-1 capsid provides a protective conical enclosure for the transport of the viral genome to its integration sites inside the nucleus. The capsid must uncoat to release the newly formed vDNA and to establish a permanent…
Posted May 21, 2026
Tracking Adverse prenatal Brain Stressors on offspring development (TABS)
US Eunice Kennedy Shriver National Institute of Child Health and Human Development · grant
PROJECT SUMMARY A growing body of published research links heightened maternal psychological distress (MPD) during pregnancy to an increased risk of adverse outcomes for the pregnant mother herself as well as for her offspring, including im…
Posted May 21, 2026
Symbiotic-based discovery of turbinmicin, a safe and selective antifungal against resistant fungi
US · IL NIH · grant
New antifungal drugs are needed to address the emergence of pan-drug resistant fungal pathogens that threaten a growing immunocompromised patient population. Underscoring this urgency is the recent global spread of Candida auris, which is r…
Posted May 21, 2026